PMID- 23461369
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20131121
IS  - 1211-9059 (Print)
IS  - 1211-9059 (Linking)
VI  - 68
IP  - 5
DP  - 2012 Nov
TI  - [Pars plana vitrectomy and combination therapy pars plana vitrectomy, 
      intravitreal triamcinolon acetonid and macular lasercoagulation - one year 
      results].
PG  - 180-8
AB  - PURPOSE: To compare anatomic and functional results of pars plana vitrectomy with 
      MLI peeling (group PPV) and pars plana vitrectomy with MLI peeling, intravitreal 
      triamcinolon acetonide 4 mg and macular lasercoagulation (group PPV + TRIAM) in 
      eyes with diffuse diabetic macular edema (DEM). METHODS: In the group PPV eyes 
      underwent PPV with MLI peeling and in the group PPV + TRIAM, PPV with MLI 
      peeling, intravitreal triamcinolon acetonide 4 mg was performed at the end of 
      surgery and macular lasercoagulation 3 weeks after surgery. Best corrected visual 
      acuity (BCVA), central macular thickness (CMT) and macular volume were recorded 
      before, 1, 3, 6 and 12 months after vitrectomy. RESULTS: Sixty - eight eyes from 
      59 subjects with DEM non responsive to lasercoagulation or with vitreomacular 
      traction were enrolled, the group PPV 35 eyes and the group PPV + TRIAM 33 eyes. 
      In the group PPV before and 1, 3, 6 a 12 months after surgery mean BCVA were 
      0,22; 0,21; 0,28; 0,32; 0,30, mean CMT were 497,69 mum; 400,89 mum; 356,46 mum; 
      346,89 mum; 319,49 mum and mean macular volume were 11,48 mm3; 9,82 mm3; 9,28 mm3; 
      9,07 mm3, 8,83 mm3. In the group PPV + TRIAM mean BCVA were 0,18; 0,16; 0,23; 
      0,26; 0,26, mean CMT were 447,82 mum; 276,03 mum; 266,27 mum; 268,36 mum; 251,15 mum, 
      mean macular volume were 10,71 mm3; 8,03 mm3; 8,28 mm3; 7,96 mm3; 7,66 mm3. In 
      both groups statistical significant improvement in BCVA were observed from month 
      3 (p = 0.0013), in CMT and macular volume from month 1 (< 0.001). To compare both 
      groups, in the group PPV + TRIAM changes in CMT and macular volume in month 1 
      after combination therapy from baseline were statistical significant, but without 
      statistical significant, change in BCVA (p = 0.229). The major complications 
      after surgery were an elevation of intraocular pressure and cataract surgery, 
      more often in the group PPV + TRIAM (p = 0.153, p = 0.056). CONCLUSION: Both 
      surgical technics are effective in the treatment of DEM. Combination therapy PPV, 
      triamcinolon acetonide 4mg and macular lasercoagulation is associated with higher 
      number of complications after surgery (elevation of intraocular pressure and 
      cataract surgery).
FAU - Stefanickova, J
AU  - Stefanickova J
AD  - Klinika oftalmologie LFUK a UNUB Bratislava. jstefanicka@gmail.com
FAU - Strmen, P
AU  - Strmen P
FAU - Vavrova, K
AU  - Vavrova K
FAU - Mrozova, L
AU  - Mrozova L
FAU - Krasnik, V
AU  - Krasnik V
LA  - slo
PT  - English Abstract
PT  - Journal Article
TT  - Pars plana vitrektomia a kombinovana liecba pars plana vitrektomia, triamcinolon 
      acetonid intravitrealne a laserkoagulacia makuly pri diabetickom edeme makuly - 
      rocne vysledky.
PL  - Czech Republic
TA  - Cesk Slov Oftalmol
JT  - Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a 
      Slovenske oftalmologicke spolecnosti
JID - 9600515
RN  - 0 (Glucocorticoids)
RN  - F446C597KA (Triamcinolone Acetonide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Combined Modality Therapy
MH  - Diabetic Retinopathy/complications/physiopathology/*therapy
MH  - Female
MH  - Glucocorticoids/*administration & dosage
MH  - Humans
MH  - *Laser Coagulation
MH  - Macular Edema/etiology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Triamcinolone Acetonide/*administration & dosage
MH  - Visual Acuity
MH  - *Vitrectomy
MH  - Vitreous Body
EDAT- 2013/03/07 06:00
MHDA- 2013/09/21 06:00
CRDT- 2013/03/07 06:00
PHST- 2013/03/07 06:00 [entrez]
PHST- 2013/03/07 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - 39817 [pii]
PST - ppublish
SO  - Cesk Slov Oftalmol. 2012 Nov;68(5):180-8.