PMID- 23461616 OWN - NLM STAT- MEDLINE DCOM- 20131211 LR - 20221207 IS - 1651-2227 (Electronic) IS - 0803-5253 (Linking) VI - 102 IP - 6 DP - 2013 Jun TI - Association between brain-derived neurothropic factor variants and asthma in Chinese Han children. PG - e247-50 LID - 10.1111/apa.12224 [doi] AB - AIM: To identify the markers contributing to genetic susceptibility to asthma in Chinese Han children. METHODS: This study examined the potential association between childhood asthma and seven single nucleotide polymorphisms of Brain-derived Neurotrophic Factor (BDNF) - SNPs, rs16917204, rs6265, rs7103873, rs16917237, rs56164415, rs13306221 and rs10767664 - using the MassARRAY system. The participants, recruited between May 2009 and July 2012, were 319 children with asthma (mean age 9.82 +/- 1.57 years) recruited from a hospital paediatric department and 309 healthy controls (mean age 10.25 +/- 1.36 years), recruited from the medical examination centre at the same hospital. RESULTS: We observed a significant association for rs6265 (chi(2) = 9.851, p = 0.002, OR = 1.427, 95% CI = 1.143-1.783), located in exon 4 of the BDNF. Another potential association was observed for rs13306221 (chi(2) = 4.316, p = 0.038, OR = 1.604, 95% CI = 1.024-2.512) in the promoter region of the BDNF. Strong linkage disequilibrium was observed in block 1 (D' > 0.9). Significantly more G-G-G haplotypes in block 1 were found in children with asthma. CONCLUSIONS: These findings point to a role for BDNF polymorphisms in Chinese Han children with asthma and may inform future genetic or biological studies on childhood asthma. CI - (c)2013 Foundation Acta Paediatrica. Published by Blackwell Publishing Ltd. FAU - Yinli, Cao AU - Yinli C AD - Department of Neonatology, the First Hospital Affiliated to the Xinxiang Medical College, Xinxiang, Henan, China. caoyinli1978@163.com FAU - Jie, Hao AU - Jie H FAU - Li, Zhao AU - Li Z FAU - Jun, Gao AU - Jun G FAU - Peiling, Li AU - Peiling L FAU - Weihong, Yang AU - Weihong Y LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130325 PL - Norway TA - Acta Paediatr JT - Acta paediatrica (Oslo, Norway : 1992) JID - 9205968 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Asian People/genetics MH - Asthma/*genetics MH - Brain-Derived Neurotrophic Factor/*genetics MH - Child MH - China MH - Disease Progression MH - Female MH - *Genetic Predisposition to Disease MH - Genotype MH - Haplotypes MH - Humans MH - Linkage Disequilibrium MH - Male MH - *Polymorphism, Single Nucleotide EDAT- 2013/03/07 06:00 MHDA- 2013/12/16 06:00 CRDT- 2013/03/07 06:00 PHST- 2013/01/09 00:00 [received] PHST- 2013/02/03 00:00 [revised] PHST- 2013/02/27 00:00 [accepted] PHST- 2013/03/07 06:00 [entrez] PHST- 2013/03/07 06:00 [pubmed] PHST- 2013/12/16 06:00 [medline] AID - 10.1111/apa.12224 [doi] PST - ppublish SO - Acta Paediatr. 2013 Jun;102(6):e247-50. doi: 10.1111/apa.12224. Epub 2013 Mar 25.