PMID- 23462596
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20130605
IS  - 1878-7533 (Electronic)
IS  - 1550-7289 (Linking)
VI  - 9
IP  - 3
DP  - 2013 May-Jun
TI  - Evidence for a metabolic mechanism in the improvement of type 2 diabetes after 
      sleeve gastrectomy in a rodent model.
PG  - 447-52
LID - S1550-7289(13)00014-2 [pii]
LID - 10.1016/j.soard.2012.12.007 [doi]
AB  - BACKGROUND: Sleeve gastrectomy (SG) is at least as effective at producing weight 
      loss as gastric banding but may be superior in producing remission of type 2 
      diabetes mellitus (T2DM). The objective of this study was to elucidate mechanisms 
      of diabetes improvement in SG beyond caloric restriction. We studied SG in Zucker 
      Diabetic Fatty (ZDF) rats. METHODS: Twenty-eight ZDF rats were randomly assigned 
      to 1 of 3 groups: SG, sham-operated ad lib fed (AL), or sham-operated pair fed 
      (PF). SG and AL rats had free access to food. PF rats were fed the average daily 
      intake of the SG group. Comparisons of caloric intake, weight loss, 
      intraperitoneal glucose tolerance testing (IPGTT), insulin, and total ghrelin 
      were performed preoperatively and at postoperative days 10, 20, and 30. 
      Differences between means were evaluated using one-way ANOVA and the paired t 
      test as appropriate. RESULTS: Postoperatively, SG rats had lower daily caloric 
      intake than the AL controls (78.3+/-10.5 kcal versus 104.7+/-4.6 kcal). Both SG and 
      PF groups had sustained weight loss (-5.3+/-3.8 g and -27.5+/-2.6 g, respectively); 
      however, SG rats had significantly lower AUC for glucose after IPGTT than both 
      controls. This is in contrast to AL controls that experienced weight gain 
      (34.1+/-4.7 g) and increases in AUC for glucose after IPGTT. CONCLUSION: Although 
      SG is considered a restrictive procedure, there is evidence for a metabolic 
      effect by virtue of decreased insulin resistance, which may not be reproduced by 
      PF controls.
CI  - Copyright (c) 2013. Published by Elsevier Inc.
FAU - Kadera, Brian E
AU  - Kadera BE
AD  - Duke University School of Medicine, Durham, NC 27704, USA.
FAU - Portenier, Dana D
AU  - Portenier DD
FAU - Yurcisin, Basil M
AU  - Yurcisin BM
FAU - Demaria, Eric J
AU  - Demaria EJ
FAU - Gaddor, Moataz M
AU  - Gaddor MM
FAU - Jain-Spangler, Kunoor
AU  - Jain-Spangler K
LA  - eng
PT  - Journal Article
DEP - 20130124
PL  - United States
TA  - Surg Obes Relat Dis
JT  - Surgery for obesity and related diseases : official journal of the American 
      Society for Bariatric Surgery
JID - 101233161
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Diabetes Mellitus, Type 2/metabolism/*surgery
MH  - Disease Models, Animal
MH  - Energy Intake
MH  - Gastrectomy/*methods
MH  - Male
MH  - Obesity/surgery
MH  - Postoperative Period
MH  - Random Allocation
MH  - Rats
MH  - Rats, Zucker
MH  - Weight Gain/physiology
MH  - Weight Loss/physiology
EDAT- 2013/03/07 06:00
MHDA- 2014/01/22 06:00
CRDT- 2013/03/07 06:00
PHST- 2012/06/05 00:00 [received]
PHST- 2012/11/18 00:00 [revised]
PHST- 2012/12/09 00:00 [accepted]
PHST- 2013/03/07 06:00 [entrez]
PHST- 2013/03/07 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
AID - S1550-7289(13)00014-2 [pii]
AID - 10.1016/j.soard.2012.12.007 [doi]
PST - ppublish
SO  - Surg Obes Relat Dis. 2013 May-Jun;9(3):447-52. doi: 10.1016/j.soard.2012.12.007. 
      Epub 2013 Jan 24.