PMID- 23462687
OWN - NLM
STAT- MEDLINE
DCOM- 20140207
LR  - 20151119
IS  - 1879-1476 (Electronic)
IS  - 0385-8146 (Linking)
VI  - 40
IP  - 5
DP  - 2013 Oct
TI  - SOX2 overexpression correlates with poor prognosis in laryngeal squamous cell 
      carcinoma.
PG  - 481-6
LID - S0385-8146(13)00035-7 [pii]
LID - 10.1016/j.anl.2013.01.003 [doi]
AB  - OBJECTIVE: The aim of present study was to investigate the expression of SOX2, a 
      key transcription factor, in LSCC and to assess its prognostic significance. 
      METHODS: SOX2 expression of 161 LSCC tissues was detected by immunohistochemistry 
      using a tissue microarray and statistically analyzed for its correlation with 
      clinicopathological charateristics and patient outcome. In addition, SOX2 
      expression was also observed in 20 self-paired fresh LSCC tissues by western 
      blot. RESULTS: SOX2 was overexpressed in LSCC tissues as compared to the 
      corresponding adjacent normal tissues. SOX2 expression was significantly 
      associated with tumour T classification (p<0.001), clinical stage (p<0.001), 
      lymph node metastasis (p=0.007) and recurrence (p=0.001). Univariate analysis 
      revealed that patients with high SOX2 expression were significantly related to 
      overall survival (p<0.001). Multivariate survival analysis further demonstrated 
      that SOX2 expression was an independent prognostic factor for LSCC patients. 
      CONCLUSION: SOX2 may contribute to the malignant progression of laryngeal 
      squamous cell carcinoma (LSCC), and present as a useful prognostic marker and a 
      potential therapeutic target for LSCC patients.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Tang, Xia-bing
AU  - Tang XB
AD  - Department of Otolaryngology, Head and Neck Surgery, Wuxi People's Hospital 
      Affiliated to Nanjing Medical University, Wuxi, Jiangsu, PR China.
FAU - Shen, Xiao-hui
AU  - Shen XH
FAU - Li, Lei
AU  - Li L
FAU - Zhang, Yi-fen
AU  - Zhang YF
FAU - Chen, Guo-qian
AU  - Chen GQ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130223
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 0 (Biomarkers)
RN  - 0 (SOX2 protein, human)
RN  - 0 (SOXB1 Transcription Factors)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/mortality
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism/mortality
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - SOXB1 Transcription Factors/*metabolism
MH  - Tissue Array Analysis
EDAT- 2013/03/07 06:00
MHDA- 2014/02/08 06:00
CRDT- 2013/03/07 06:00
PHST- 2012/09/23 00:00 [received]
PHST- 2013/01/21 00:00 [revised]
PHST- 2013/01/24 00:00 [accepted]
PHST- 2013/03/07 06:00 [entrez]
PHST- 2013/03/07 06:00 [pubmed]
PHST- 2014/02/08 06:00 [medline]
AID - S0385-8146(13)00035-7 [pii]
AID - 10.1016/j.anl.2013.01.003 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2013 Oct;40(5):481-6. doi: 10.1016/j.anl.2013.01.003. Epub 
      2013 Feb 23.