PMID- 23462948
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20220330
IS  - 1476-5640 (Electronic)
IS  - 0954-3007 (Linking)
VI  - 67
IP  - 4
DP  - 2013 Apr
TI  - Postprandial total and HMW adiponectin following a high-fat meal in lean, obese 
      and diabetic men.
PG  - 377-84
LID - 10.1038/ejcn.2013.49 [doi]
AB  - BACKGROUND/OBJECTIVES: Recent work suggests that macronutrients are 
      pro-inflammatory and promote oxidative stress. Reports of postprandial regulation 
      of total adiponectin have been mixed, and there is limited information regarding 
      postprandial changes in high molecular weight (HMW) adiponectin. The aim of this 
      study was to assess the effect of a standardised high-fat meal on metabolic 
      variables, adiponectin (total and HMW), and markers of inflammation and oxidative 
      stress in: (i) lean, (ii) obese non-diabetic and (iii) men with type 2 diabetes 
      mellitus (T2DM). SUBJECTS/METHODS: Male subjects: lean (n=10), obese (n=10) and 
      T2DM (n=10) were studied for 6 h following both a high-fat meal and water 
      control. Metabolic variables (glucose, insulin, triglycerides), inflammatory 
      markers (interleukin-6 (IL6), tumour necrosis factor (TNF)alpha, high-sensitivity 
      C-reactive protein (hsCRP), nuclear factor (NF)kappaB expression in peripheral blood 
      mononuclear cells (p65)), indicators of oxidative stress (oxidised low density 
      lipoprotein (oxLDL), protein carbonyl) and adiponectin (total and HMW) were 
      measured. RESULTS: No significant changes in TNFalpha, p65, oxLDL or protein carbonyl 
      concentrations were observed. Overall, postprandial IL6 decreased in subjects 
      with T2DM but increased in lean subjects, whereas hsCRP decreased in the lean 
      cohort and increased in obese subjects. There was no overall postprandial change 
      in total or HMW adiponectin in any group. Total adiponectin concentrations 
      changed over time following the water control, and the response was significantly 
      different in lean subjects compared with subjects with T2DM (P=0.04). 
      CONCLUSIONS: No consistent significant postprandial inflammation, oxidative 
      stress or regulation of adiponectin was observed in this study. Findings from the 
      water control suggest differential basal regulation of total adiponectin in T2DM 
      compared with lean controls.
FAU - Phillips, L K
AU  - Phillips LK
AD  - Diamantina Institute, Princess Alexandra Hospital, University of Queensland, 
      Brisbane, Queensland, Australia.
FAU - Peake, J M
AU  - Peake JM
FAU - Zhang, X
AU  - Zhang X
FAU - Hickman, I J
AU  - Hickman IJ
FAU - Briskey, D R
AU  - Briskey DR
FAU - Huang, B E
AU  - Huang BE
FAU - Simpson, P
AU  - Simpson P
FAU - Li, S-H
AU  - Li SH
FAU - Whitehead, J P
AU  - Whitehead JP
FAU - Martin, J H
AU  - Martin JH
FAU - Prins, J B
AU  - Prins JB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130306
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (NF-kappa B)
RN  - 0 (Triglycerides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (oxidized low density lipoprotein)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Blood Glucose/analysis
MH  - C-Reactive Protein/analysis/metabolism
MH  - Diabetes Mellitus, Type 2/*blood
MH  - *Diet, High-Fat
MH  - Humans
MH  - Inflammation/blood
MH  - Insulin/blood
MH  - Interleukin-6/blood
MH  - Leukocytes, Mononuclear/metabolism
MH  - Lipoproteins, LDL/blood
MH  - Male
MH  - Meals
MH  - Middle Aged
MH  - Molecular Weight
MH  - NF-kappa B/blood
MH  - Obesity/*blood
MH  - Oxidative Stress
MH  - *Postprandial Period
MH  - Thinness/*blood
MH  - Triglycerides/blood
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2013/03/07 06:00
MHDA- 2013/10/30 06:00
CRDT- 2013/03/07 06:00
PHST- 2013/03/07 06:00 [entrez]
PHST- 2013/03/07 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
AID - ejcn201349 [pii]
AID - 10.1038/ejcn.2013.49 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2013 Apr;67(4):377-84. doi: 10.1038/ejcn.2013.49. Epub 2013 Mar 
      6.