PMID- 23463453
OWN - NLM
STAT- MEDLINE
DCOM- 20131101
LR  - 20151119
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 29
IP  - 5
DP  - 2013 Jul
TI  - Positive association between high-sensitivity C-reactive protein and incidence of 
      type 2 diabetes mellitus in Japanese workers: 6-year follow-up.
PG  - 398-405
LID - 10.1002/dmrr.2406 [doi]
AB  - BACKGROUND: Elevated high-sensitivity C-reactive protein (hs-CRP), a marker of 
      low-grade systemic inflammation, may be involved in the etiology of type 2 
      diabetes mellitus (T2DM). However, whether inflammation precedes development of 
      T2DM independent of cigarette smoking and obesity remains to be confirmed. 
      METHODS: We studied 4213 civil servants in a local government in Japan aged 
      35-66 years at baseline in 2002, who donated blood samples and were followed 
      6 years. Hazard ratios (HR) of T2DM according to the hs-CRP quartiles [range Q1: 
      0.02-0.18 (reference), Q2: 0.18-0.33, Q3: 0.33-0.67 and Q4: 0.67-9.62 mg/L) were 
      estimated by Cox proportional hazards model adjusted for gender, age, body mass 
      index, alcohol intake, smoking status (current, past and never), number of 
      cigarettes per day, physical activity, family history of diabetes (Model 1) and 
      variables in Model 1 + glucose (Model 2). RESULTS: The geometric mean [95% 
      confidence interval (CI)] of hs-CRP was 0.36 mg/L (0.34-0.37). During the 
      follow-up, 156 new T2DM cases were confirmed. In total sample, Model 2 HRs (95% 
      CIs) for hs-CRP quartiles Q2-Q4 compared with Q1 were 0.69 (0.36-1.26), 1.47 
      (0.91-2.39) and 1.78 (1.10-2.88), respectively (p for linear trend = 0.014). 
      Stratified analysis revealed that a statistically significant association was 
      observed only in normal weight non-current smokers with Model 2 HRs (CIs) being 
      0.79 (0.29-2.17), 2.63 (1.25-5.56) and 3.19 (1.49-6.86) for Q2-Q4 compared with 
      Q1, respectively (p for linear trend = 0.0006). The relationship did not change 
      materially after further adjusting for log-homeostasis model assessment or 
      exclusion of past smokers. CONCLUSIONS: These findings imply that higher hs-CRP 
      itself or existence of chronic systemic inflammation precedes onset of T2DM 
      independent of obesity and smoking.
CI  - Copyright (c) 2013 John Wiley & Sons, Ltd.
FAU - Wang, Chaochen
AU  - Wang C
AD  - Department of Public Health and Health Systems, Nagoya University Graduate School 
      of Medicine, Nagoya, Japan.
FAU - Yatsuya, Hiroshi
AU  - Yatsuya H
FAU - Tamakoshi, Koji
AU  - Tamakoshi K
FAU - Uemura, Mayu
AU  - Uemura M
FAU - Li, Yuanying
AU  - Li Y
FAU - Wada, Keiko
AU  - Wada K
FAU - Yamashita, Kentaro
AU  - Yamashita K
FAU - Kawaguchi, Leo
AU  - Kawaguchi L
FAU - Toyoshima, Hideaki
AU  - Toyoshima H
FAU - Aoyama, Atsuko
AU  - Aoyama A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - C-Reactive Protein/*analysis
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/complications/epidemiology/ethnology/*immunology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Insulin Resistance
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Overweight/complications
MH  - Proportional Hazards Models
MH  - Suburban Health/ethnology
MH  - Urban Health/ethnology
OTO - NOTNLM
OT  - cohort study
OT  - hs-CRP
OT  - incidence
OT  - overweight
OT  - smoking status
OT  - type 2 diabetes
EDAT- 2013/03/07 06:00
MHDA- 2013/11/02 06:00
CRDT- 2013/03/07 06:00
PHST- 2012/11/12 00:00 [received]
PHST- 2013/02/03 00:00 [revised]
PHST- 2013/02/13 00:00 [accepted]
PHST- 2013/03/07 06:00 [entrez]
PHST- 2013/03/07 06:00 [pubmed]
PHST- 2013/11/02 06:00 [medline]
AID - 10.1002/dmrr.2406 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2013 Jul;29(5):398-405. doi: 10.1002/dmrr.2406.