PMID- 23463679
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20130723
IS  - 1552-4965 (Electronic)
IS  - 1549-3296 (Linking)
VI  - 101
IP  - 9
DP  - 2013 Sep
TI  - Early inflammatory response in soft tissues induced by thin calcium phosphates.
PG  - 2712-7
LID - 10.1002/jbm.a.34571 [doi]
AB  - The inflammatory response to titanium and hydroxyapatite (HA)-coated titanium in 
      living tissue is controlled by a number of humoral factors, of which monocyte 
      chemoattractant protein-1 (MCP-1) has been specifically linked to the recruitment 
      of monocytes. These cells subsequently mature into tissue-bound macrophages. 
      Macrophages adhering to the proteins adsorbed at the implant surface play a 
      pivotal role in initiating the rejection or integration of the foreign material. 
      Despite this, little is known about the initial inflammatory events that occur in 
      soft tissues following the implantation of titanium and HA-coated titanium 
      implants. In this study, circular discs of commercially pure titanium (c.p. Ti) 
      with either a thin crystalline HA coating or amorphous HA coating or uncoated 
      were implanted subcutaneously into rats. The implants were retrieved after 24 and 
      72 h. The lactate dehydrogenase (LD) activity, DNA content, expression of MCP-1, 
      interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-alpha), as well as monocyte and 
      polymorphonuclear granulocyte counts in the exudate surrounding the implants were 
      analyzed. There were significantly higher DNA and LD levels around the titanium 
      implants at 24 h compared with HA-coated titanium. A rapid decrease in MCP-1 
      levels was observed for all the implants over the period of observation. No 
      statistically significant differences were found between the two HA-coated 
      implants. Our results suggest a difference in the early soft-tissue response to 
      HA-coated implants when compared with titanium implants, expressed as a 
      downregulation of inflammatory cell recruitment. This suggests that thin HA 
      coatings are promising surfaces for soft tissue applications.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Ryden, L
AU  - Ryden L
AD  - Department of Biomaterials, Sahlgrenska Academy at University of Gothenburg, 
      Goteborg, Sweden.
FAU - Molnar, D
AU  - Molnar D
FAU - Esposito, M
AU  - Esposito M
FAU - Johansson, A
AU  - Johansson A
FAU - Suska, F
AU  - Suska F
FAU - Palmquist, A
AU  - Palmquist A
FAU - Thomsen, P
AU  - Thomsen P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130305
PL  - United States
TA  - J Biomed Mater Res A
JT  - Journal of biomedical materials research. Part A
JID - 101234237
RN  - 0 (Calcium Phosphates)
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Cytokines)
RN  - 91D9GV0Z28 (Durapatite)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Animals
MH  - Calcium Phosphates/*chemistry
MH  - Chemokine CCL2/metabolism
MH  - Coated Materials, Biocompatible/chemistry
MH  - Cytokines/metabolism
MH  - Durapatite/chemistry
MH  - Female
MH  - Inflammation/*etiology/metabolism/pathology
MH  - Macrophages/metabolism/pathology
MH  - Materials Testing
MH  - Monocytes/metabolism/pathology
MH  - Prostheses and Implants/*adverse effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Titanium/*chemistry
OTO - NOTNLM
OT  - cytokines
OT  - hydroxyapatite
OT  - implant
OT  - inflammation
OT  - macrophages
OT  - monocytes
OT  - titanium
EDAT- 2013/03/07 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/03/07 06:00
PHST- 2012/10/30 00:00 [received]
PHST- 2012/12/11 00:00 [revised]
PHST- 2012/12/17 00:00 [accepted]
PHST- 2013/03/07 06:00 [entrez]
PHST- 2013/03/07 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1002/jbm.a.34571 [doi]
PST - ppublish
SO  - J Biomed Mater Res A. 2013 Sep;101(9):2712-7. doi: 10.1002/jbm.a.34571. Epub 2013 
      Mar 5.