PMID- 23464972
OWN - NLM
STAT- MEDLINE
DCOM- 20130819
LR  - 20171116
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 63
IP  - 2
DP  - 2013 Feb
TI  - CD4 and CD8 double-negative adult T-cell leukemia/lymphoma with monomorphic cells 
      expressing CD99: a diagnostic challenge in a country non-endemic for human T-cell 
      leukemia virus.
PG  - 132-7
LID - 10.1111/pin.12040 [doi]
AB  - Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell neoplasm caused by 
      human T-cell lymphotropic virus type I (HTLV-I). The neoplastic cells are highly 
      pleomorphic and are usually CD4+ and CD8- phenotypically. We reported the case of 
      a 46-year-old woman presenting with fever, abdominal distention, lymphadenopathy, 
      leukocytosis and hypercalcemia. Nodal biopsy showed diffuse infiltration by 
      monomorphic small to medium-sized atypical lymphocytes expressing CD3, CD25, CD30 
      and CD99, but not CD1a, CD4, CD8, CD34, terminal deoxynucleotidyl transferase or 
      ALK. An initial diagnosis of T-lymphoblastic leukemia/lymphoma was made based on 
      cytomorphology, CD4 and CD8 double negativity, and the expression of CD99. The 
      diagnosis was later revised to ATLL based on the positive serology study for 
      anti-HTLV I/II antibody and confirmation by the clonal integration of HTLV-I 
      proviral DNA into the tumor tissues by Southern blotting analysis. The patient 
      had a stage IVB disease and died of septic shock after 2 courses of chemotherapy 
      3 months after diagnosis. Immunohistochemical staining for CD99 in archival ATLL 
      tissues showed a positive rate of 67% (4 of 6 tumors). Our case showed that ATLL 
      with atypical morphology and immunophenotype in HTLV non-endemic areas might pose 
      a diagnostic challenge and CD99 expression is frequent in ATLL.
CI  - (c) 2013 The Authors. Pathology International (c) 2013 Japanese Society of Pathology 
      and Wiley Publishing Asia Pty Ltd.
FAU - Lin, Tsung-Hsien
AU  - Lin TH
AD  - Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan.
FAU - Wu, Hung-Chang
AU  - Wu HC
FAU - Hsieh, Yen-Chuan
AU  - Hsieh YC
FAU - Tseng, Chih-En
AU  - Tseng CE
FAU - Ichinohasama, Ryo
AU  - Ichinohasama R
FAU - Chuang, Shih-Sung
AU  - Chuang SS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (12E7 Antigen)
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
RN  - 0 (CD99 protein, human)
RN  - 0 (Cell Adhesion Molecules)
SB  - IM
MH  - 12E7 Antigen
MH  - Antigens, CD/analysis/*biosynthesis
MH  - Biomarkers, Tumor/*analysis
MH  - Biopsy
MH  - CD4 Antigens
MH  - CD8 Antigens
MH  - Cell Adhesion Molecules/analysis/*biosynthesis
MH  - *Diagnostic Errors
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - Leukemia-Lymphoma, Adult T-Cell/*diagnosis/*immunology
MH  - Middle Aged
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/immunology
EDAT- 2013/03/08 06:00
MHDA- 2013/08/21 06:00
CRDT- 2013/03/08 06:00
PHST- 2012/12/02 00:00 [received]
PHST- 2013/01/29 00:00 [accepted]
PHST- 2013/03/08 06:00 [entrez]
PHST- 2013/03/08 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - 10.1111/pin.12040 [doi]
PST - ppublish
SO  - Pathol Int. 2013 Feb;63(2):132-7. doi: 10.1111/pin.12040.