PMID- 23465891
OWN - NLM
STAT- MEDLINE
DCOM- 20140825
LR  - 20131209
IS  - 1879-1700 (Electronic)
IS  - 0265-931X (Linking)
VI  - 127
DP  - 2014 Jan
TI  - The low dose gamma ionising radiation impact upon cooperativity of 
      androgen-specific proteins.
PG  - 182-90
LID - S0265-931X(13)00036-2 [pii]
LID - 10.1016/j.jenvrad.2013.02.002 [doi]
AB  - The paper deals with effects of the ionising radiation (gamma-IR, 0.5 Gy) upon serum 
      testosterone (T), characteristics of testosterone-binding globulin (TeBG) and 
      androgen receptor (AR) in parallel with observation of androgen (A) responsive 
      enzyme activity - hexokinase (HK). The interdependence or relationships of 
      T-levels with parameters of the proteins that provide androgenic regulation are 
      consequently analyzed in post-IR dynamics. The IR-stress adjustment data reveal 
      expediency of TeBG- and AR-cooperativity measurements for more precise 
      assessments of endocrine A-control at appropriate emergencies.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Filchenkov, Gennady N
AU  - Filchenkov GN
AD  - Lab. of Biochemistry, Institute of Radiobiology, National Academy of Sciences of 
      Belarus, Feduninskogo 4, Gomel 246007, Belarus.
FAU - Popoff, Eugene H
AU  - Popoff EH
FAU - Naumov, Alexander D
AU  - Naumov AD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130305
PL  - England
TA  - J Environ Radioact
JT  - Journal of environmental radioactivity
JID - 8508119
RN  - 0 (Receptors, Androgen)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Radiation
MH  - Gamma Rays/*adverse effects
MH  - Hexokinase/*blood
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Androgen/*blood
MH  - Sex Hormone-Binding Globulin/analysis
MH  - Testosterone/blood
OTO - NOTNLM
OT  - (h)TeBG
OT  - 5alpha-dihydrotestosterone
OT  - A
OT  - ABP
OT  - AC
OT  - AR
OT  - ARC
OT  - Androgenic receptor
OT  - Androgens
OT  - B
OT  - B(max)
OT  - B(nsp)
OT  - B(t)
OT  - ChNPP
OT  - Chernobyl nuclear power plant
OT  - DCC
OT  - DF
OT  - DHT
OT  - Hb
OT  - Hexokinase
OT  - IR
OT  - ISS
OT  - International Space Station
OT  - Ionising radiation
OT  - K(a)
OT  - K(d)
OT  - MF
OT  - MT
OT  - OF
OT  - PM
OT  - SIS
OT  - T
OT  - T(add)
OT  - Testosterone-binding globulin
OT  - U
OT  - aa
OT  - adenylate cyclase
OT  - amino acids
OT  - androgen receptor
OT  - androgen receptor complex
OT  - androgen(s)
OT  - androgen-binding protein of rat i.e. (r)TeBG
OT  - dextran-coated charcoal (1:9)
OT  - dimerization factor
OT  - equilibrium association constant
OT  - equilibrium dissociation constant
OT  - external plasma(tic) membrane of cell
OT  - final concentration of [(3)H]-DHT added in incubation system
OT  - hemoglobin
OT  - human testosterone-binding globulin
OT  - ionising radiation
OT  - maximal B' value calculated by approximation in Scatchard plot
OT  - methyltrienolone
OT  - monomerization factor
OT  - nonspecific binding of A
OT  - oligomerization factor
OT  - quantity of specifically bound A ([(3)H]-DHT by TeBG and [(3)H]-MT by RA)
OT  - standard incubation system
OT  - testosterone
OT  - the Hill coefficient indicating a degree of cooperativity for A-binding by TeBG 
      or AR (calculated in Hill plot, see Figs. 2 and 3)
OT  - total binding of [(3)H]-A
OT  - unbound [(3)H]-A that removed by DCC after incubation
OT  - eta(Hill)
EDAT- 2013/03/08 06:00
MHDA- 2014/08/26 06:00
CRDT- 2013/03/08 06:00
PHST- 2011/09/01 00:00 [received]
PHST- 2013/01/23 00:00 [revised]
PHST- 2013/02/10 00:00 [accepted]
PHST- 2013/03/08 06:00 [entrez]
PHST- 2013/03/08 06:00 [pubmed]
PHST- 2014/08/26 06:00 [medline]
AID - S0265-931X(13)00036-2 [pii]
AID - 10.1016/j.jenvrad.2013.02.002 [doi]
PST - ppublish
SO  - J Environ Radioact. 2014 Jan;127:182-90. doi: 10.1016/j.jenvrad.2013.02.002. Epub 
      2013 Mar 5.