PMID- 23466425
OWN - NLM
STAT- MEDLINE
DCOM- 20140318
LR  - 20220321
IS  - 1943-3654 (Electronic)
IS  - 0020-1324 (Linking)
VI  - 58
IP  - 8
DP  - 2013 Aug
TI  - Genetic polymorphism of transforming growth factor beta1 and tumor necrosis factor alpha 
      is associated with asthma and modulates the severity of asthma.
PG  - 1343-50
LID - 10.4187/respcare.02187 [doi]
AB  - BACKGROUND: The role of transforming growth factor beta1 (TGF-beta1) and tumor necrosis 
      factor alpha (TNF-alpha) in asthma is unclear. The aim of this study was to assess the 
      relationships among polymorphisms, clinical phenotypes, and the serum levels of 
      TGF-beta1 and TNF-alpha. METHODS: Polymorphisms of promoter of TGF-beta1 (C-509T locus) and 
      TNF-alpha (G-308 A locus; rs 1800629) in 217 asthmatic patients and 110 healthy 
      controls were evaluated. Pulmonary function, total immunoglobulin E (IgE), 
      specific IgE antibodies, total eosinophil counts, TGF-beta1, and TNF-alpha were 
      assessed. RESULTS: The genetic polymorphisms of TGF-beta1 promoter and TNF-alpha were 
      significantly associated with asthma. Subjects with more severe asthma had higher 
      serum levels of TGF-beta1 and TNF-alpha. In asthmatic subjects the TGF-beta1 of atopic 
      subjects was higher than those without atopy. All studied subjects (asthma plus 
      control) were divided into 4 groups by mean value of TGF-beta1 or TNF-alpha. The high 
      values of TGF-beta1 or TNF-alpha were defined by higher than the mean values of the 
      studied subjects of TGF-beta1 (392.42 pg/mL) and TNF-alpha (55.86 pg/mL). The FEV1 of 
      the group with high TGF-beta1 plus low TNF-alpha was lower than that in the group with 
      low TGF-beta1 plus low TNF-alpha. The lowest FEV1 was in the group with high TNF-alpha and 
      high TGF-beta1. CONCLUSIONS: The genetic polymorphisms of TGF-beta1 and TNF-alpha are 
      associated with asthma. TGF-beta1 modulates atopy. Both TGF-beta1 and TNF-alpha modulate 
      clinical severity and airway obstruction, in an additive manner.
FAU - Chiang, Chi-Huei
AU  - Chiang CH
AD  - Division of Pulmonary Immunology and Infectious Diseases, Chest Department, 
      Taipei Veterans General Hospital, Taipei, Taiwan. chiang1990@gmail.com
FAU - Chuang, Chiao-Hui
AU  - Chuang CH
FAU - Liu, Shiou-Ling
AU  - Liu SL
FAU - Shen, Horng-Der
AU  - Shen HD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130306
PL  - United States
TA  - Respir Care
JT  - Respiratory care
JID - 7510357
RN  - 0 (Transforming Growth Factor beta1)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Airway Obstruction/genetics
MH  - Asthma/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Severity of Illness Index
MH  - Transforming Growth Factor beta1/blood/*genetics
MH  - Tumor Necrosis Factor-alpha/blood/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - asthma
OT  - phenotype
OT  - transforming growth factor beta1
OT  - tumor necrosis factor
EDAT- 2013/03/08 06:00
MHDA- 2014/03/19 06:00
CRDT- 2013/03/08 06:00
PHST- 2013/03/08 06:00 [entrez]
PHST- 2013/03/08 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
AID - respcare.02187 [pii]
AID - 10.4187/respcare.02187 [doi]
PST - ppublish
SO  - Respir Care. 2013 Aug;58(8):1343-50. doi: 10.4187/respcare.02187. Epub 2013 Mar 
      6.