PMID- 23466764
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20220408
IS  - 0300-5283 (Print)
IS  - 0300-5283 (Linking)
VI  - 68
IP  - 1
DP  - 2013
TI  - Association between Serum 25 (OH) Vitamin D Concentrations and Inflammatory Bowel 
      Diseases (IBDs) Activity.
PG  - 34-8
AB  - Inflammatory bowel diseases (IBDs) are immune mediated diseases affecting the 
      gastrointestinal tract. Several environmental factors in concert with genetic 
      susceptibilities can trigger IBDs. Recently, one of the important environmental 
      factors contributing to the development of autoimmune diseases is vitamin D 
      (VitD) deficiency. Furthermore, some new evidence points to VitD deficiency and 
      its receptor dysfunction as an underlying factor for the emergence experimental 
      IBDs. The aim of the current study was to evaluate the correlation between serum 
      25(OH)D concentrations and IBD activity in patients with ulcerative colitis or 
      Crohn's disease. Sixty patients with confirmed diagnosis of IBD were recruited 
      for a cross sectional study. Most of the identified confounders affecting serum 
      VitD concentrations were excluded. Disease activity was assessed using validated 
      questionnaires, including Truelove for Ulcerative Colitis and Crohn Disease 
      Activity Index (CDAI) for Crohn disease. Serum 25(OH)D concentrations were 
      determined by chemiluminescent assay. Serum 25(OH)D</=10 (ng/ml) was considered as 
      VitD deficiency and 11</=25(OH)D<29(ng/ml) as VitD insufficiency. Mean serum 
      25(OH)D value was 13.1 +/- 11.1(ng/ml) in IBD patients. Almost 95% of patients were 
      vitamin D insufficient or deficient. Forty one percent of IBD patients had active 
      disease. VitD deficiency was not associated with IBD activity (p=0.23). However, 
      VitD deficiency was significantly associated with a history of IBD related 
      intestinal surgery (p=0.001). In conclusion, this cross-sectional prospective 
      study suggested that there is no association between vitamin D deficiency and 
      disease activity in a relatively small number of IBD patients in a short period 
      of time.
FAU - Hassan, V
AU  - Hassan V
AD  - Mashhad University of Medical Sciences, Department of Internal Medicine, Faculty 
      of Medicine, Mashhad University of Medical Sciences, Ghaem Hospital, Mashhad, 
      Iran.
FAU - Hassan, S
AU  - Hassan S
FAU - Seyed-Javad, P
AU  - Seyed-Javad P
FAU - Ahmad, K
AU  - Ahmad K
FAU - Asieh, H
AU  - Asieh H
FAU - Maryam, S
AU  - Maryam S
FAU - Farid, F
AU  - Farid F
FAU - Siavash, A
AU  - Siavash A
LA  - eng
PT  - Journal Article
PL  - Malaysia
TA  - Med J Malaysia
JT  - The Medical journal of Malaysia
JID - 0361547
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Inflammatory Bowel Diseases
MH  - Prospective Studies
MH  - *Vitamin D
MH  - *Vitamin D Deficiency
EDAT- 2013/03/08 06:00
MHDA- 2016/04/24 06:00
CRDT- 2013/03/08 06:00
PHST- 2013/03/08 06:00 [entrez]
PHST- 2013/03/08 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
PST - ppublish
SO  - Med J Malaysia. 2013;68(1):34-8.