PMID- 23468912
OWN - NLM
STAT- MEDLINE
DCOM- 20130823
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 2
DP  - 2013
TI  - Intravenous administration of achyranthes bidentata polypeptides supports 
      recovery from experimental ischemic stroke in vivo.
PG  - e57055
LID - 10.1371/journal.pone.0057055 [doi]
LID - e57055
AB  - BACKGROUND: Achyranthes bidentata Blume (A. bidentata) is a commonly prescribed 
      Chinese medicinal herb. A. bidentata polypeptides (ABPP) is an active composite 
      constituent, separated from the aqueous extract of A. bidentata. Our previous 
      studies have found that ABPP have the neuroprotective function in vitro and in 
      rat middle cerebral artery occlusion (MCAO) model in attenuating the brain 
      infract area induced by focal ischemia-reperfusion. However, the ultimate goal of 
      the stroke treatment is the restoration of behavioral function. Identifying 
      behavioral deficits and therapeutic treatments in animal models of ischemic 
      stroke is essential for potential translational applications. METHODOLOGY AND 
      PRINCIPAL FINDINGS: The effect of ABPP on motor, sensory, and cognitive function 
      in an ischemic stroke model with MCAO was investigated up to day 30. The function 
      recovery monitored by the neurological deficit score, grip test, body asymmetry, 
      beam-balancing task, and the Morris Water Maze. In this study, systemic 
      administration of ABPP by i.v after MCAO decreased the neurological deficit 
      score, ameliorated the forepaw muscle strength, and diminished the motor and 
      sensory asymmetry on 7(th) and 30(th) day after MCAO. MCAO has been observed to 
      cause prolonged disturbance of spatial learning and memory in rats using the MWM, 
      and ABPP treatment could improve the spatial learning and memory function, which 
      is impaired by MCAO in rats, on 30(th) day after MCAO. Then, the viable cells in 
      CA1 region of hippocampus were counted by Nissl staining, and the neuronal cell 
      death were significantly suppressed in the ABPP treated group. CONCLUSION: ABPP 
      could improve the recovery of sensory, motor and coordination, and cognitive 
      function in MCAO-induced ischemic rats. And this recovery had a good correlation 
      to the less of neuronal injury in brain.
FAU - Shen, Hongmei
AU  - Shen H
AD  - Key Laboratory of Neuroregeneration and Institute of Nautical Medicine, Nantong 
      University, Nantong, China. hmshen1971@gmail.com
FAU - Wu, Xinmin
AU  - Wu X
FAU - Zhu, Yuzhong
AU  - Zhu Y
FAU - Sun, Hualing
AU  - Sun H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130226
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Peptides)
SB  - IM
MH  - Achyranthes/*chemistry
MH  - Administration, Intravenous
MH  - Animals
MH  - Cerebral Infarction/drug therapy/pathology/physiopathology
MH  - Disease Models, Animal
MH  - Learning/drug effects
MH  - Male
MH  - Memory/drug effects
MH  - Neurons/drug effects/pathology
MH  - Neuroprotective Agents/administration & dosage
MH  - Peptides/*administration & dosage
MH  - Psychomotor Performance/drug effects
MH  - Rats
MH  - Stroke/*drug therapy/mortality/pathology
MH  - Thermosensing/drug effects
PMC - PMC3582638
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/03/08 06:00
MHDA- 2013/08/24 06:00
PMCR- 2013/02/26
CRDT- 2013/03/08 06:00
PHST- 2012/08/26 00:00 [received]
PHST- 2013/01/17 00:00 [accepted]
PHST- 2013/03/08 06:00 [entrez]
PHST- 2013/03/08 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
PHST- 2013/02/26 00:00 [pmc-release]
AID - PONE-D-12-25949 [pii]
AID - 10.1371/journal.pone.0057055 [doi]
PST - ppublish
SO  - PLoS One. 2013;8(2):e57055. doi: 10.1371/journal.pone.0057055. Epub 2013 Feb 26.