PMID- 23469118
OWN - NLM
STAT- MEDLINE
DCOM- 20130829
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 2
DP  - 2013
TI  - Brain-derived neurotrophic factor--a major player in stimulation-induced 
      homeostatic metaplasticity of human motor cortex?
PG  - e57957
LID - 10.1371/journal.pone.0057957 [doi]
LID - e57957
AB  - Repetitive transcranial magnetic stimulation (rTMS) of the human motor hand area 
      (M1HAND) can induce lasting changes in corticospinal excitability as indexed by a 
      change in amplitude of the motor-evoked potential. The plasticity-inducing 
      effects of rTMS in M1HAND show substantial inter-individual variability which has 
      been partially attributed to the val(66)met polymorphism in the brain-derived 
      neurotrophic factor (BDNF) gene. Here we used theta burst stimulation (TBS) to 
      examine whether the BDNF val(66)met genotype can be used to predict the 
      expression of TBS-induced homeostatic metaplasticity in human M1HAND. TBS is a 
      patterned rTMS protocol with intermittent TBS (iTBS) usually inducing a lasting 
      increase and continuous TBS (cTBS) a lasting decrease in corticospinal 
      excitability. In three separate sessions, healthy val(66)met (n = 12) and 
      val(66)val (n = 17) carriers received neuronavigated cTBS followed by cTBS 
      (n = 27), cTBS followed by iTBS (n = 29), and iTBS followed by iTBS (n = 28). 
      Participants and examiner were blinded to the genotype at the time of 
      examination. As expected, the first TBS intervention induced a decrease (cTBS) 
      and increase (iTBS) in corticospinal excitability, respectively, at the same time 
      priming the after effects caused by the second TBS intervention in a homeostatic 
      fashion. Critically, val(66)met carriers and val(66)val carriers showed very 
      similar response patterns to cTBS and iTBS regardless of the order of TBS 
      interventions. Since none of the observed TBS effects was modulated by the BDNF 
      val(66)met polymorphism, our results do not support the notion that the BDNF 
      val(66)met genotype is a major player with regard to TBS-induced plasticity and 
      metaplasticity in the human M1HAND.
FAU - Mastroeni, Claudia
AU  - Mastroeni C
AD  - Department of Neurology, Christian-Albrechts-University, Kiel, Germany.
FAU - Bergmann, Til Ole
AU  - Bergmann TO
FAU - Rizzo, Vincenzo
AU  - Rizzo V
FAU - Ritter, Christoph
AU  - Ritter C
FAU - Klein, Christine
AU  - Klein C
FAU - Pohlmann, Ines
AU  - Pohlmann I
FAU - Brueggemann, Norbert
AU  - Brueggemann N
FAU - Quartarone, Angelo
AU  - Quartarone A
FAU - Siebner, Hartwig Roman
AU  - Siebner HR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130228
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Evoked Potentials, Motor
MH  - Genotype
MH  - *Homeostasis
MH  - Humans
MH  - Male
MH  - Motor Cortex/metabolism/*physiology
MH  - *Neuronal Plasticity
MH  - Time Factors
MH  - *Transcranial Magnetic Stimulation
PMC - PMC3585283
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/03/08 06:00
MHDA- 2013/08/30 06:00
PMCR- 2013/02/28
CRDT- 2013/03/08 06:00
PHST- 2012/10/09 00:00 [received]
PHST- 2013/01/29 00:00 [accepted]
PHST- 2013/03/08 06:00 [entrez]
PHST- 2013/03/08 06:00 [pubmed]
PHST- 2013/08/30 06:00 [medline]
PHST- 2013/02/28 00:00 [pmc-release]
AID - PONE-D-12-31236 [pii]
AID - 10.1371/journal.pone.0057957 [doi]
PST - ppublish
SO  - PLoS One. 2013;8(2):e57957. doi: 10.1371/journal.pone.0057957. Epub 2013 Feb 28.