PMID- 23469779
OWN - NLM
STAT- MEDLINE
DCOM- 20140429
LR  - 20130916
IS  - 1539-6924 (Electronic)
IS  - 0272-4332 (Linking)
VI  - 33
IP  - 9
DP  - 2013 Sep
TI  - Health risk characterization of chlorpyrifos using epidemiological dose-response 
      data and probabilistic techniques: a case study with rice farmers in Vietnam.
PG  - 1596-607
LID - 10.1111/risa.12023 [doi]
AB  - Various methods for risk characterization have been developed using probabilistic 
      approaches. Data on Vietnamese farmers are available for the comparison of 
      outcomes for risk characterization using different probabilistic methods. This 
      article addresses the health risk characterization of chlorpyrifos using 
      epidemiological dose-response data and probabilistic techniques obtained from a 
      case study with rice farmers in Vietnam. Urine samples were collected from 
      farmers and analyzed for trichloropyridinol (TCP), which was converted into 
      absorbed daily dose of chlorpyrifos. Adverse health response doses due to 
      chlorpyrifos exposure were collected from epidemiological studies to develop 
      dose-adverse health response relationships. The health risk of chlorpyrifos was 
      quantified using hazard quotient (HQ), Monte Carlo simulation (MCS), and overall 
      risk probability (ORP) methods. With baseline (prior to pesticide spraying) and 
      lifetime exposure levels (over a lifetime of pesticide spraying events), the HQ 
      ranged from 0.06 to 7.1. The MCS method indicated less than 0.05% of the 
      population would be affected while the ORP method indicated that less than 1.5% 
      of the population would be adversely affected. With postapplication exposure 
      levels, the HQ ranged from 1 to 32.5. The risk calculated by the MCS method was 
      that 29% of the population would be affected, and the risk calculated by ORP 
      method was 33%. The MCS and ORP methods have advantages in risk characterization 
      due to use of the full distribution of data exposure as well as dose response, 
      whereas HQ methods only used the exposure data distribution. These evaluations 
      indicated that single-event spraying is likely to have adverse effects on 
      Vietnamese rice farmers.
CI  - (c) 2013 Society for Risk Analysis.
FAU - Phung, Dung Tri
AU  - Phung DT
AD  - Centre for Environment and Population Health, Griffith University, 170 Kessel 
      Road, Nathan, QLD 4111, Australia.
FAU - Connell, Des
AU  - Connell D
FAU - Yu, Qiming
AU  - Yu Q
FAU - Chu, Cordia
AU  - Chu C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130307
PL  - United States
TA  - Risk Anal
JT  - Risk analysis : an official publication of the Society for Risk Analysis
JID - 8109978
RN  - 0 (Environmental Pollutants)
RN  - 0 (Pesticides)
RN  - 0 (Pyridones)
RN  - 6515-38-4 (3,5,6-trichloro-2-pyridinol)
RN  - JCS58I644W (Chlorpyrifos)
SB  - IM
MH  - *Agriculture
MH  - Chlorpyrifos/*analysis/toxicity
MH  - Dose-Response Relationship, Drug
MH  - Environmental Exposure
MH  - Environmental Monitoring
MH  - Environmental Pollutants/toxicity
MH  - Humans
MH  - Monte Carlo Method
MH  - *Occupational Exposure
MH  - Pesticides/*analysis/toxicity
MH  - Probability
MH  - Proportional Hazards Models
MH  - Pyridones/*analysis/toxicity
MH  - Reproducibility of Results
MH  - Risk Assessment/*methods
MH  - Vietnam
OTO - NOTNLM
OT  - Chlorpyrifos
OT  - health risk characterization
OT  - probabilistic risk assessment
OT  - rice farmers
EDAT- 2013/03/09 06:00
MHDA- 2014/04/30 06:00
CRDT- 2013/03/09 06:00
PHST- 2013/03/09 06:00 [entrez]
PHST- 2013/03/09 06:00 [pubmed]
PHST- 2014/04/30 06:00 [medline]
AID - 10.1111/risa.12023 [doi]
PST - ppublish
SO  - Risk Anal. 2013 Sep;33(9):1596-607. doi: 10.1111/risa.12023. Epub 2013 Mar 7.