PMID- 23469798 OWN - NLM STAT- MEDLINE DCOM- 20140130 LR - 20130308 IS - 1000-503X (Print) IS - 1000-503X (Linking) VI - 35 IP - 1 DP - 2013 Feb TI - [Metabolic complications and quality of life in prostate cancer patients after receiving endocrine treatment]. PG - 88-94 LID - 10.3881/j.issn.1000-503X.2013.01.017 [doi] AB - OBJECTIVE: To compare the incidences of anemia, osteoporosis, and irritable bowel syndrome (IBS) after the application of different endocrine therapies in patients with prostate cancer. METHODS: Totally 125 patients aged 58 to 84 years with biopsy-confirmed local prostate cancer were recruited between September 2008 and September 2010. Of them 52 treated with orchiectomy (castration group) and 73 with luteinizing hormone-releasing hormone analogue (goserelin acetate 3.6mg/month) combined with androgen antagonist (bicalutamide 50mg/d) for at least 12 months (hormone group), but without blood transfusion or erythropoietin. Changes in total testosterone (TT), free testosterone (FT), prostate specific antigen (PSA), hemoglobin (Hb), red blood cell (RBC), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), bone mineral density (BMD) and gastrointestinal symptom rating scales (GSRS) were recorded and analyzed before treatment and 12 months after the initiation of treatment. RESULTS: In the castration group, after 12 months, TT (P=0.0007), FT (P=0.0003), PSA (P=0.0006), Hb (P=0.0001), RBC (P=0.020), Hct (P=0.016), Z-score of lumbar spine (P=0.008), and femoral neck (P=0.004) decreased significantly, and GSRS (P=0.029) increased significantly. In hormone group, after 12 months, TT (P=0.0008), FT (P=0.0006), PSA (P=0.0006), Hb (P=0.0003), RBC (P=0.0001), Hct (P=0.0002), Z-score of lumbar spine (P=0.002), femoral neck (P=0.0002), and RDW (P=0.045) decreased significantly, and GSRS (P=0.010) increased significantly. After 12 months, TT (P=0.004), FT (P=0.012), PSA (P=0.007), Hb (P=0.016), Z-score of lumbar spine (P=0.033), and femoral neck (P=0.015) in hormone group were significantly lower than in the castration group, while GSRS (P=0.027) in hormone group was significantly higher than in the castration group. The incidences of anemia (P=0.006), osteoporosis (P=0.009), and IBS (P=0.022) were significantly different between these two groups. The serum level of testosterone was positively correlated with Hb, RBC, Hct, and BMD in both groups (P=0.039). Negative linear correlations could be seen between serum level of testosterone and GSRS in both groups (P=0.021), and between serum level of testosterone and RDW in medical group only (P=0.044). CONCLUSION: The endocrine therapies, particularly maximal androgen blockage, in patients with prostate cancer can be associated with anemia, osteoporosis, and IBS. FAU - Yuan, Jia-qi AU - Yuan JQ AD - Department of Urology, Peking University People's Hospital, Beijing, China. FAU - Xu, Tao AU - Xu T FAU - Zhang, Xiao-wei AU - Zhang XW FAU - Wang, Xiao-feng AU - Wang XF LA - chi PT - Comparative Study PT - English Abstract PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - China TA - Zhongguo Yi Xue Ke Xue Yuan Xue Bao JT - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JID - 8006230 SB - IM MH - Aged MH - Aged, 80 and over MH - Anemia/*etiology MH - Bone Density/physiology MH - Humans MH - Incidence MH - Irritable Bowel Syndrome/*etiology MH - Male MH - Middle Aged MH - Osteoporosis/*etiology MH - Prostatic Neoplasms/complications/*physiopathology/therapy MH - *Quality of Life EDAT- 2013/03/09 06:00 MHDA- 2014/01/31 06:00 CRDT- 2013/03/09 06:00 PHST- 2013/03/09 06:00 [entrez] PHST- 2013/03/09 06:00 [pubmed] PHST- 2014/01/31 06:00 [medline] AID - 10.3881/j.issn.1000-503X.2013.01.017 [doi] PST - ppublish SO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2013 Feb;35(1):88-94. doi: 10.3881/j.issn.1000-503X.2013.01.017.