PMID- 23470887
OWN - NLM
STAT- MEDLINE
DCOM- 20131217
LR  - 20190918
IS  - 1882-0654 (Electronic)
IS  - 0009-918X (Linking)
VI  - 53
IP  - 2
DP  - 2013
TI  - [Severe olfactory dysfunction is a predictor of dementia with Parkinson's 
      disease].
PG  - 91-7
AB  - Recently, we identified that hyposmia, one of the most typical non-motor features 
      in Parkinson's disease (PD), was a predictive feature of PDD (Parkinson's disease 
      dementia). The multivariate logistic analysis identified severe hyposmia and 
      visuoperceptual impairment as independent risk factors for subsequent dementia 
      within 3 years. The patients with severe hyposmia had an 18.7-fold increase in 
      their risk of dementia for each 1 SD (2.8) decrease in the score of odor stick 
      identification test for Japanese (OSIT-J). We also found an association between 
      severe hyposmia and a characteristic distribution of cerebral metabolic decline, 
      which was identical to the findings observed in PDD. Furthermore, volumetric 
      magnetic resonance imaging analyses demonstrated close relationships between 
      olfactory dysfunction and the atrophy of focal brain structures, including the 
      amygdala and other limbic structures. Dementia is one of the most debilitating 
      symptoms of PD. Despite its clinical importance, the development of dementia is 
      still difficult to predict at early stages. As cognitive impairments are known to 
      be associated with poor prognoses in PD, olfactory tests may be a useful tool for 
      the management of PD cases especially in advanced stages.
FAU - Takeda, Atsushi
AU  - Takeda A
AD  - Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku 
      University Graduate School of Medicine.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
SB  - IM
MH  - Aged
MH  - Awards and Prizes
MH  - Dementia/*etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Olfaction Disorders/*complications/etiology
MH  - Parkinson Disease/*complications
EDAT- 2013/03/09 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/03/09 06:00
PHST- 2013/03/09 06:00 [entrez]
PHST- 2013/03/09 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - DN/JST.JSTAGE/clinicalneurol/53.91 [pii]
AID - 10.5692/clinicalneurol.53.91 [doi]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2013;53(2):91-7. doi: 10.5692/clinicalneurol.53.91.