PMID- 23471370
OWN - NLM
STAT- MEDLINE
DCOM- 20131105
LR  - 20211021
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Print)
IS  - 1618-2642 (Linking)
VI  - 405
IP  - 12
DP  - 2013 May
TI  - Oral fluid and plasma 3,4-methylenedioxymethamphetamine (MDMA) and metabolite 
      correlation after controlled oral MDMA administration.
PG  - 4067-76
LID - 10.1007/s00216-013-6848-7 [doi]
AB  - Oral fluid (OF) offers a noninvasive sample collection for drug testing. However, 
      3,4-methylenedioxymethamphetamine (MDMA, ecstasy) in OF has not been adequately 
      characterized in comparison to plasma. We administered oral low-dose (1.0 mg/kg) 
      and high-dose (1.6 mg/kg) MDMA to 26 participants and collected simultaneous OF 
      and plasma specimens for up to 143 h after dosing. We compared OF/plasma (OF/P) 
      ratios, time of initial detection (t first), maximal concentrations (C max), time 
      of peak concentrations (t max), time of last detection (t last), clearance, and 
      3,4-methylenedioxyamphetamine (MDA)-to-MDMA ratios over time. For OF MDMA and 
      MDA, C max was higher, t last was later, and clearance was slower compared to 
      plasma. For OF MDA only, t first was later compared to plasma. Median (range) 
      OF/P ratios were 5.6 (0.1-52.3) for MDMA and 3.7 (0.7-24.3) for MDA. OF and 
      plasma concentrations were weakly but significantly correlated (MDMA: R(2) = 
      0.438, MDA: R(2) = 0.197, p < 0.0001). Median OF/P ratios were significantly 
      higher following high dose administration: MDMA low = 5.2 (0.1-40.4), high = 6.0 
      (0.4-52.3, p < 0.05); MDA low = 3.3 (0.7-17.1), high = 4.1 (0.9-24.3, p < 0.001). 
      There was a large inter-subject variation in OF/P ratios. The MDA/MDMA ratios in 
      plasma were higher than those in OF (p < 0.001), and the MDA/MDMA ratios 
      significantly increased over time in OF and plasma. The MDMA and MDA 
      concentrations were higher in OF than in plasma. OF and plasma concentrations 
      were correlated, but large inter-subject variability precludes the estimation of 
      plasma concentrations from OF.
FAU - Desrosiers, Nathalie A
AU  - Desrosiers NA
AD  - Chemistry and Drug Metabolism Section, Clinical Pharmacology and Therapeutic 
      Research Branch, NIDA IRP, Baltimore, MD 21224, USA.
FAU - Barnes, Allan J
AU  - Barnes AJ
FAU - Hartman, Rebecca L
AU  - Hartman RL
FAU - Scheidweiler, Karl B
AU  - Scheidweiler KB
FAU - Kolbrich-Spargo, Erin A
AU  - Kolbrich-Spargo EA
FAU - Gorelick, David A
AU  - Gorelick DA
FAU - Goodwin, Robert S
AU  - Goodwin RS
FAU - Huestis, Marilyn A
AU  - Huestis MA
LA  - eng
GR  - ZIA DA000412-13/Intramural NIH HHS/United States
GR  - ZIA DA000468-06/Intramural NIH HHS/United States
GR  - Z01 DA000414-10/Intramural NIH HHS/United States
GR  - Z01 DA000414-11/Intramural NIH HHS/United States
GR  - Z01 DA000412-10/Intramural NIH HHS/United States
GR  - ZIA DA000414-12/Intramural NIH HHS/United States
GR  - ZIA DA000412-12/Intramural NIH HHS/United States
GR  - ZIA DA000468-08/Intramural NIH HHS/United States
GR  - ZIA DA000468-09/Intramural NIH HHS/United States
GR  - Z01 DA000412-11/Intramural NIH HHS/United States
GR  - Z01 DA000468-05/Intramural NIH HHS/United States
GR  - ZIA DA000414-13/Intramural NIH HHS/United States
GR  - ZIA DA000468-07/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20130308
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Administration, Oral
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & 
      dosage/blood/*metabolism/*pharmacokinetics
MH  - Saliva/*metabolism
MH  - Substance Abuse Detection
MH  - Young Adult
PMC - PMC3638040
MID - NIHMS449773
EDAT- 2013/03/09 06:00
MHDA- 2013/11/06 06:00
PMCR- 2014/05/01
CRDT- 2013/03/09 06:00
PHST- 2012/12/31 00:00 [received]
PHST- 2013/02/14 00:00 [accepted]
PHST- 2013/02/11 00:00 [revised]
PHST- 2013/03/09 06:00 [entrez]
PHST- 2013/03/09 06:00 [pubmed]
PHST- 2013/11/06 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - 10.1007/s00216-013-6848-7 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2013 May;405(12):4067-76. doi: 10.1007/s00216-013-6848-7. Epub 
      2013 Mar 8.