PMID- 23472126
OWN - NLM
STAT- MEDLINE
DCOM- 20131203
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 3
DP  - 2013
TI  - The association between polymorphisms in the MRPL4 and TNF-alpha genes and 
      susceptibility to allergic rhinitis.
PG  - e57981
LID - 10.1371/journal.pone.0057981 [doi]
LID - e57981
AB  - BACKGROUND: Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal 
      mucosa, involving a complex interaction between genetic and environmental 
      factors. Evidence suggests that polymorphisms in the gene coding for 
      mitochondrial ribosomal protein L4 (MRPL4), located in close proximity to 
      intercellular adhesion molecule-1 (ICAM-1) gene on chromosome location 19p13.2, 
      may influence the risk factor for the development of AR. OBJECTIVE: The aim of 
      our study was to investigate any association between AR susceptibility and 
      polymorphisms in ICAM-1 gene, as well as associations between AR risk and 
      polymorphisms in MRPL4, nuclear factor-kappaB (NF-kappaB) and tumor necrosis factor 
      alpha(TNF-alpha) genes, associated with ICAM-1 expression. METHODS: A cohort of 414 
      patients with AR and 293 healthy controls was enrolled from the Han Chinese 
      population in Beijing, China. Blood was drawn for DNA extraction and total serum 
      immunoglobulin E (IgE). A total of 14 single nucleotide polymorphisms (SNPs) in 
      ICAM-1, NF-kappaB, TNF-alpha, and MRPL4 genes were selected using the CHB genotyping data 
      from the International Haplotype Mapping (HapMap) and assessed for differences in 
      frequencies of the alleles and genotypes between the AR patients and control 
      subjects. RESULTS: TNF-alpha SNP rs1799964 and MRPL4 SNP rs11668618 were found to 
      occur in significantly greater frequencies in the AR group compared to control 
      group. There were no significant associations between SNPs in NF-kappaB, ICAM-1 and 
      AR. The SNP-SNP interaction information analysis further indicated that there 
      were no synergistic effects among the selected sets of polymorphisms. 
      CONCLUSIONS: Our results suggest a strong association between AR risk and 
      polymorphisms of MRPL4 and TNF-alpha genes in Han Chinese population.
FAU - Wei, Xin
AU  - Wei X
AD  - Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, 
      Capital Medical University, Beijing, PR China.
FAU - Zhang, Yuan
AU  - Zhang Y
FAU - Fu, Zheng
AU  - Fu Z
FAU - Zhang, Luo
AU  - Zhang L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130305
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (MRPL4 protein, human)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Ribosomal Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Chromosome Mapping
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/genetics
MH  - Male
MH  - Middle Aged
MH  - Mitochondrial Proteins/*genetics
MH  - NF-kappa B/metabolism
MH  - *Polymorphism, Single Nucleotide
MH  - Rhinitis, Allergic
MH  - Rhinitis, Allergic, Perennial/ethnology/*genetics
MH  - Ribosomal Proteins/*genetics
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Young Adult
PMC - PMC3589466
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/03/09 06:00
MHDA- 2013/12/16 06:00
PMCR- 2013/03/05
CRDT- 2013/03/09 06:00
PHST- 2012/09/28 00:00 [received]
PHST- 2013/01/30 00:00 [accepted]
PHST- 2013/03/09 06:00 [entrez]
PHST- 2013/03/09 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2013/03/05 00:00 [pmc-release]
AID - PONE-D-12-29864 [pii]
AID - 10.1371/journal.pone.0057981 [doi]
PST - ppublish
SO  - PLoS One. 2013;8(3):e57981. doi: 10.1371/journal.pone.0057981. Epub 2013 Mar 5.