PMID- 23473004
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20130418
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 35
IP  - 4
DP  - 2013
TI  - Comparison of kidney paired donation transplantations with living related donor 
      kidney transplantation: implications for national kidney paired donation program.
PG  - 504-8
LID - 10.3109/0886022X.2013.773914 [doi]
AB  - BACKGROUND: Kidney Paired Donation (KPD) is a rapidly growing modality for 
      facilitating living related donor kidney transplantation (LRDKTx) for patients 
      who are incompatible with their healthy, willing, and living donors. Data 
      scarcity on the outcome of KPD versus LRDKTx prompted us to review our 
      experience. MATERIALS AND METHODS: This was a single-center study of 224 patients 
      on regular follow-up, who underwent LRDRTx from January 2010 to June 2012 at our 
      institute. The aim of this study was to compare short-term graft survival, 
      patient survival and rejection rates of KPD (group 1, n = 34) with those of 
      LRDKTx (group 2, n = 190). All the recipients received triple immunosuppression 
      and thymoglobulin induction in KPD group. Kaplan-Meier curves were used for 
      survival analysis. In group 1, mean recipient age was 35.5 +/- 13.2 years, 29 were 
      men and mean donor age was 44.4 +/- 8.17 years, 10 were men. In group 2, mean 
      recipient age was 29.1 +/- 10 years, 155 were men and mean donor age was 47.5 +/- 
      9.69 years, 74 were men. Mean human leukocyte antigen (HLA) matching in group 1 
      and 2 was 1 versus 3.2 (p < 0.05). RESULTS: One- and two-year patient survival 
      showed no significant difference between the two groups (97.1%, 97.1% vs. 96.2%, 
      94.8%, respectively, p = 0.81). Death-censored graft survival also showed no 
      significant difference between the two groups (97.1%, 97.1%, vs. 97.6%, 97.6%, p 
      = 0.73). Acute rejection incidence was also similar (8.7% vs. 9.9%, p > 0.62). 
      CONCLUSIONS: Our study showed similar graft survival, patient survival and 
      rejection rates of KPD versus LRDKTx over 2 years post-transplantation, 
      encouraging the use of this approach for national KPD program.
FAU - Kute, Vivek B
AU  - Kute VB
AD  - Department of Nephrology and Clinical Transplantation, Institute of Kidney 
      Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation 
      Sciences (IKDRC-ITS), Ahmedabad, India. drvivekkute@rediffmail.com
FAU - Gumber, Manoj R
AU  - Gumber MR
FAU - Vanikar, Aruna V
AU  - Vanikar AV
FAU - Shah, Pankaj R
AU  - Shah PR
FAU - Patel, Himanshu V
AU  - Patel HV
FAU - Engineer, Divyesh P
AU  - Engineer DP
FAU - Modi, Pranjal R
AU  - Modi PR
FAU - Rizvi, Jamal S
AU  - Rizvi JS
FAU - Shah, Veena R
AU  - Shah VR
FAU - Trivedi, Hargovind L
AU  - Trivedi HL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130311
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adult
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection/*epidemiology
MH  - *Graft Survival
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Kidney Transplantation/*methods/mortality
MH  - Living Donors/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Survival Analysis
MH  - Tissue and Organ Procurement/*methods/statistics & numerical data
MH  - Treatment Outcome
EDAT- 2013/03/12 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/03/12 06:00
PHST- 2013/03/12 06:00 [entrez]
PHST- 2013/03/12 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.3109/0886022X.2013.773914 [doi]
PST - ppublish
SO  - Ren Fail. 2013;35(4):504-8. doi: 10.3109/0886022X.2013.773914. Epub 2013 Mar 11.