PMID- 23473656
OWN - NLM
STAT- MEDLINE
DCOM- 20140530
LR  - 20131018
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 209
IP  - 3
DP  - 2013 Oct 30
TI  - Assessment of the minimum clinically important difference in quality of life in 
      schizophrenia measured by the Quality of Well-Being Scale and disease-specific 
      measures.
PG  - 291-6
LID - S0165-1781(13)00037-1 [pii]
LID - 10.1016/j.psychres.2013.01.016 [doi]
AB  - This study examines the psychometric properties of the Quality of Well Being 
      Scale (QWB), the Positive and Negative Syndrome Scale (PANSS), the 
      Heinrich-Carpenter Quality of Life Scale (QOLS), and the Lenert PANSS-based 
      utility measure in a cohort of patients with schizophrenia and identifies 
      threshold values of clinically meaningful change using the Clinical Global 
      Impressions scale (CGI), as the anchor. The correlation of these measures at 
      baseline and change at 6 and 12 months post enrollment in a comparative 
      effectiveness trial was evaluated in 350 veterans with schizophrenia or 
      schizoaffective disorder. An equipercentile method was used to estimate the 
      minimum clinically important difference (MCID) for each measure. Effect size of 
      0.30-0.50 for baseline quality of life associated with inpatient status supported 
      concurrent validity. The QWB was moderately correlated with disease-specific 
      measures. The MCID as detected by the CGI at 6 months was 0.17 for QWB, 0.15 for 
      the Lenert utility score, 1.13 for the QOLS, and 20.2 for the PANSS. These 
      differences were stable at 12 months. The QWB is significantly correlated with 
      disease specific measures of health related quality of life in schizophrenia.
CI  - Published by Elsevier Ireland Ltd.
FAU - Thwin, Soe Soe
AU  - Thwin SS
AD  - VA-Boston Healthcare System, Boston, MA, USA; Boston University, Department of 
      Biostatistics, Boston, MA, USA. Electronic address: soesoe.thwin@va.gov.
FAU - Hermes, Eric
AU  - Hermes E
FAU - Lew, Robert
AU  - Lew R
FAU - Barnett, Paul
AU  - Barnett P
FAU - Liang, Matthew
AU  - Liang M
FAU - Valley, Danielle
AU  - Valley D
FAU - Rosenheck, Robert
AU  - Rosenheck R
LA  - eng
SI  - ClinicalTrials.gov/NCT00132314
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20130307
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adult
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Psychometrics/*methods
MH  - Quality of Life/*psychology
MH  - Schizophrenia/*diagnosis
MH  - *Schizophrenic Psychology
MH  - Time Factors
MH  - Veterans
OTO - NOTNLM
OT  - Clinical trials
OT  - Equipercentile Linkage
OT  - Minimum clinically important differences
OT  - Quality of life
OT  - Schizophrenia
OT  - Utility
EDAT- 2013/03/12 06:00
MHDA- 2014/05/31 06:00
CRDT- 2013/03/12 06:00
PHST- 2012/05/08 00:00 [received]
PHST- 2013/01/11 00:00 [revised]
PHST- 2013/01/12 00:00 [accepted]
PHST- 2013/03/12 06:00 [entrez]
PHST- 2013/03/12 06:00 [pubmed]
PHST- 2014/05/31 06:00 [medline]
AID - S0165-1781(13)00037-1 [pii]
AID - 10.1016/j.psychres.2013.01.016 [doi]
PST - ppublish
SO  - Psychiatry Res. 2013 Oct 30;209(3):291-6. doi: 10.1016/j.psychres.2013.01.016. 
      Epub 2013 Mar 7.