PMID- 23474438
OWN - NLM
STAT- MEDLINE
DCOM- 20140108
LR  - 20131111
IS  - 1879-1220 (Electronic)
IS  - 0960-0760 (Linking)
VI  - 138
DP  - 2013 Nov
TI  - Steroid receptor coactivator-1: a versatile regulator and promising therapeutic 
      target for breast cancer.
PG  - 17-23
LID - S0960-0760(13)00041-1 [pii]
LID - 10.1016/j.jsbmb.2013.02.010 [doi]
AB  - Breast cancer is the leading cause of cancer death for women worldwide. Various 
      therapeutic approaches have been proposed, among which endocrine therapy has 
      recently become popular due to the high sensitivity of breast tissues to steroids 
      such as estrogens and progesterone. The underlying mechanisms of steroid 
      regulation in breast cancer cell proliferation, invasiveness, metastasis and 
      endocrine resistance, however, remain largely unknown. Steroid receptor 
      coactivator-1 (SRC-1) has attracted much attention because it is an important 
      co-regulator and plays a pivotal role in modulating the transcriptional 
      activities of steroid nuclear receptors. Accumulated research has established a 
      strong correlation between SRC-1 and the pathological progression or 
      disease-related features of breast cancer, which supports its potential as a 
      target for specific therapeutic intervention in the clinical management of breast 
      cancer. In addition, a diverse group of downstream molecules have also been shown 
      to participate in various functional pathways related to SRC-1-associated 
      regulation of breast cancer. These downstream molecules are also considered 
      promising therapeutic targets, providing additional options for targeted 
      treatments. In this review, the expression of SRC-1 in breast cancer and the 
      close relationships between SRC-1 and the cell proliferation, invasiveness, 
      metastasis and endocrine resistance of breast cancer will be discussed, followed 
      by a brief summary of its putative functional mechanisms with an emphasis on the 
      potential therapeutic role of SRC-1.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Zhang, Yanlei
AU  - Zhang Y
AD  - Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Third 
      Military Medical University, Chongqing 400038, China; Company Ten of Cadet 
      Brigade, Third Military Medical University, Chongqing 400038, China.
FAU - Duan, Chenyang
AU  - Duan C
FAU - Bian, Chen
AU  - Bian C
FAU - Xiong, Ying
AU  - Xiong Y
FAU - Zhang, Jiqiang
AU  - Zhang J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130306
PL  - England
TA  - J Steroid Biochem Mol Biol
JT  - The Journal of steroid biochemistry and molecular biology
JID - 9015483
RN  - EC 2.3.1.48 (Nuclear Receptor Coactivator 1)
SB  - IM
MH  - Animals
MH  - Breast Neoplasms/*metabolism
MH  - Cell Proliferation
MH  - Female
MH  - Humans
MH  - Neoplasm Metastasis
MH  - Nuclear Receptor Coactivator 1/*metabolism
MH  - Signal Transduction/physiology
OTO - NOTNLM
OT  - Breast cancer
OT  - Coactivator
OT  - Endocrine resistance
OT  - Metastasis
OT  - Steroid receptor coactivator-1
EDAT- 2013/03/12 06:00
MHDA- 2014/01/09 06:00
CRDT- 2013/03/12 06:00
PHST- 2012/11/24 00:00 [received]
PHST- 2013/02/06 00:00 [revised]
PHST- 2013/02/19 00:00 [accepted]
PHST- 2013/03/12 06:00 [entrez]
PHST- 2013/03/12 06:00 [pubmed]
PHST- 2014/01/09 06:00 [medline]
AID - S0960-0760(13)00041-1 [pii]
AID - 10.1016/j.jsbmb.2013.02.010 [doi]
PST - ppublish
SO  - J Steroid Biochem Mol Biol. 2013 Nov;138:17-23. doi: 10.1016/j.jsbmb.2013.02.010. 
      Epub 2013 Mar 6.