PMID- 23474999
OWN - NLM
STAT- MEDLINE
DCOM- 20131022
LR  - 20220316
IS  - 1873-3379 (Electronic)
IS  - 0891-4222 (Linking)
VI  - 34
IP  - 5
DP  - 2013 May
TI  - Neural underpinnings of impaired predictive motor timing in children with 
      Developmental Coordination Disorder.
PG  - 1478-87
LID - S0891-4222(13)00066-8 [pii]
LID - 10.1016/j.ridd.2013.02.008 [doi]
AB  - A dysfunction in predictive motor timing is put forward to underlie DCD-related 
      motor problems. Predictive timing allows for the pre-selection of motor 
      programmes (except 'program' in computers) in order to decrease processing load 
      and facilitate reactions. Using functional magnetic resonance imaging (fMRI), 
      this study investigated the neural correlates of motor timing in DCD (n=17) and 
      typically developing children (n=17). The task involved motor responses to 
      sequences of visual stimuli with predictive or unpredictive interstimulus 
      intervals (ISIs). DCD children responded with a smaller reaction time (RT) 
      advantage to predictive ISIs compared to typically developing children. Typically 
      developing children exhibited higher activation in the right dorsolateral 
      prefrontal cortex (DLPFC) and right inferior frontal gyrus (IFG) for responses at 
      unpredictive as opposed to predictive ISIs, whereas activations in DCD children 
      were non-differentiable. Moreover, DCD children showed less activation than 
      typically developing children in the right DLPFC, the left posterior cerebellum 
      (crus I) and the right temporo-parietal junction (TPJ) for this contrast. 
      Notably, activation in the right temporo-parietal junction (TPJ) positively 
      correlated with RT as an indicator of processing load in both groups. These data 
      indicate that motor performance in DCD children requires extra processing demands 
      due to impaired predictive encoding.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Debrabant, Julie
AU  - Debrabant J
AD  - Department of Rehabilitation Sciences and Physiotherapy, Ghent University and 
      Artevelde University College, Campus Heymans Ghent University Hospital - 2B3 
      (REVAKI), De Pintelaan 185, 9000 Ghent, Belgium. Julie.debrabant@ugent.be
FAU - Gheysen, Freja
AU  - Gheysen F
FAU - Caeyenberghs, Karen
AU  - Caeyenberghs K
FAU - Van Waelvelde, Hilde
AU  - Van Waelvelde H
FAU - Vingerhoets, Guy
AU  - Vingerhoets G
LA  - eng
PT  - Journal Article
DEP - 20130305
PL  - United States
TA  - Res Dev Disabil
JT  - Research in developmental disabilities
JID - 8709782
SB  - IM
MH  - Anticipation, Psychological/physiology
MH  - Brain/*physiology
MH  - Cerebellum/physiology
MH  - Child
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Motor Cortex/physiology
MH  - Motor Skills/*physiology
MH  - Motor Skills Disorders/*physiopathology
MH  - Parietal Lobe/physiology
MH  - Predictive Value of Tests
MH  - Prefrontal Cortex/physiology
MH  - Psychomotor Performance/*physiology
MH  - Reaction Time/physiology
EDAT- 2013/03/12 06:00
MHDA- 2013/10/23 06:00
CRDT- 2013/03/12 06:00
PHST- 2012/12/15 00:00 [received]
PHST- 2013/02/04 00:00 [revised]
PHST- 2013/02/05 00:00 [accepted]
PHST- 2013/03/12 06:00 [entrez]
PHST- 2013/03/12 06:00 [pubmed]
PHST- 2013/10/23 06:00 [medline]
AID - S0891-4222(13)00066-8 [pii]
AID - 10.1016/j.ridd.2013.02.008 [doi]
PST - ppublish
SO  - Res Dev Disabil. 2013 May;34(5):1478-87. doi: 10.1016/j.ridd.2013.02.008. Epub 
      2013 Mar 5.