PMID- 23475599
OWN - NLM
STAT- MEDLINE
DCOM- 20130828
LR  - 20220331
IS  - 1534-312X (Electronic)
IS  - 1522-8037 (Print)
IS  - 1522-8037 (Linking)
VI  - 15
IP  - 4
DP  - 2013 Apr
TI  - Ambulatory reflux monitoring in GERD--which test should be performed and should 
      therapy be stopped?
PG  - 316
LID - 10.1007/s11894-013-0316-6 [doi]
AB  - Diagnosing gastroesophageal reflux disease (GERD) often entails using a 
      combination of patient symptoms, response to proton pump inhibitors (PPI), upper 
      endoscopy, and ambulatory reflux testing. Each of these has limitations of which 
      the clinician must be aware when managing patients with reflux symptoms. 
      Ambulatory reflux monitoring, in particular, can potentially document the true 
      presence of pathologic GERD. Consequently, reflux testing is often necessary in 
      our evaluation of patients with reflux symptoms, and can be useful in 
      distinguishing etiologies driving a lack of response to PPI therapy. Reflux 
      testing results can be also used to guide appropriate PPI prescribing and 
      clinical decision making for appropriate or unnecessary therapy. This review 
      focuses on the limitations of our current diagnostic paradigm and highlights how 
      reflux testing can be helpful in the diagnosis and management of patients with 
      poor response to PPI therapy.
FAU - Gawron, Andrew J
AU  - Gawron AJ
AD  - Department of Medicine, The Feinberg School of Medicine, Northwestern University, 
      676 St Clair St, Suite 1400, Chicago, IL 60611-2951, USA.
FAU - Pandolfino, John E
AU  - Pandolfino JE
LA  - eng
GR  - R01 DK079902/DK/NIDDK NIH HHS/United States
GR  - T32 HS000078/HS/AHRQ HHS/United States
GR  - T-32 HS 000078/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Curr Gastroenterol Rep
JT  - Current gastroenterology reports
JID - 100888896
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Algorithms
MH  - Endoscopy, Gastrointestinal/methods
MH  - *Esophageal pH Monitoring
MH  - Gastroesophageal Reflux/*diagnosis/drug therapy
MH  - Humans
MH  - Monitoring, Ambulatory/*methods
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Treatment Failure
PMC - PMC3626104
MID - NIHMS454111
EDAT- 2013/03/12 06:00
MHDA- 2013/08/29 06:00
PMCR- 2014/04/01
CRDT- 2013/03/12 06:00
PHST- 2013/03/12 06:00 [entrez]
PHST- 2013/03/12 06:00 [pubmed]
PHST- 2013/08/29 06:00 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - 10.1007/s11894-013-0316-6 [doi]
PST - ppublish
SO  - Curr Gastroenterol Rep. 2013 Apr;15(4):316. doi: 10.1007/s11894-013-0316-6.