PMID- 23476101
OWN - NLM
STAT- MEDLINE
DCOM- 20130819
LR  - 20220409
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2013
DP  - 2013
TI  - Plasma progranulin concentrations are increased in patients with type 2 diabetes 
      and obesity and correlated with insulin resistance.
PG  - 360190
LID - 10.1155/2013/360190 [doi]
LID - 360190
AB  - Insulin resistance (IR) is considered to be one of the most important 
      pathogenesis of glycolipid metabolism disorders. However, the molecular mechanism 
      responsible for IR is not fully understood. Recently, the chronic inflammation 
      has been proposed to be involved in the pathogenesis of IR. In this study, we aim 
      to investigate the concentrations of plasma progranulin in Chinese patients with 
      obesity (OB) and type 2 diabetes mellitus (T2DM), and its relationship to IR. 
      Plasma progranulin concentrations were significantly higher in the T2DM patients 
      than in the normal glucose tolerant (NGT) subjects (P < 0.01). Within the T2DM 
      and the NGT patients, the concentrations of progranulin were significantly higher 
      in obese subjects than that in the normal weight subjects (225.22 +/- 34.39 ng/mL 
      versus 195.59 +/- 50.47 ng/mL and 183.79 +/- 61.63 ng/mL versus 148.69 +/- 55.27 ng/mL, 
      P < 0.05). Plasma progranulin concentrations correlated positively with weight, 
      waist circumferences, BMI, HbA1c, TG, IL-6, FINS and HOMA-IR (P < 0.05), while 
      correlated negatively with HOMA- beta (P < 0.05). Multiple linear regression 
      analysis showed that BMI, HbA1c, IL-6 and TG correlated independently with 
      circulating progranulin concentrations (P < 0.05). These results suggested that 
      Plasma progranulin concentrations were higher in Chinese patients with type 2 
      diabetes and obesity and correlated closely with glycolipid metabolism, chronic 
      inflammation and IR.
FAU - Qu, Hua
AU  - Qu H
AD  - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing 400016, China.
FAU - Deng, Huacong
AU  - Deng H
FAU - Hu, Zhenping
AU  - Hu Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130217
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (GRN protein, human)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Progranulins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Weight/physiology
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Insulin Resistance/*physiology
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood
MH  - Progranulins
MH  - Waist Circumference/physiology
PMC - PMC3588183
EDAT- 2013/03/12 06:00
MHDA- 2013/08/21 06:00
PMCR- 2013/02/17
CRDT- 2013/03/12 06:00
PHST- 2012/11/13 00:00 [received]
PHST- 2013/01/08 00:00 [accepted]
PHST- 2013/03/12 06:00 [entrez]
PHST- 2013/03/12 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
PHST- 2013/02/17 00:00 [pmc-release]
AID - 10.1155/2013/360190 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2013;2013:360190. doi: 10.1155/2013/360190. Epub 2013 Feb 17.