PMID- 23476654 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20130312 LR - 20231106 IS - 1687-9104 (Print) IS - 1687-9112 (Electronic) VI - 2013 DP - 2013 TI - Dendritic cell development: a choose-your-own-adventure story. PG - 949513 LID - 10.1155/2013/949513 [doi] LID - 949513 AB - Dendritic cells (DCs) are essential components of the immune system and contribute to immune responses by activating or tolerizing T cells. DCs comprise a heterogeneous mixture of subsets that are located throughout the body and possess distinct and specialized functions. Although numerous defined precursors from the bone marrow and spleen have been identified, emerging data in the field suggests many alternative routes of DC differentiation from precursors with multilineage potential. Here, we discuss how the combinatorial expression of transcription factors can promote one DC lineage over another as well as the integration of cytokine signaling in this process. FAU - Moore, Amanda J AU - Moore AJ AD - Division of Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5 ; Department of Immunology, University of Toronto, Toronto, ON, Canada M5S 1A8. FAU - Anderson, Michele K AU - Anderson MK LA - eng PT - Journal Article DEP - 20130218 PL - United States TA - Adv Hematol JT - Advances in hematology JID - 101504271 PMC - PMC3588201 EDAT- 2013/03/12 06:00 MHDA- 2013/03/12 06:01 PMCR- 2013/02/18 CRDT- 2013/03/12 06:00 PHST- 2012/11/05 00:00 [received] PHST- 2012/12/27 00:00 [accepted] PHST- 2013/03/12 06:00 [entrez] PHST- 2013/03/12 06:00 [pubmed] PHST- 2013/03/12 06:01 [medline] PHST- 2013/02/18 00:00 [pmc-release] AID - 10.1155/2013/949513 [doi] PST - ppublish SO - Adv Hematol. 2013;2013:949513. doi: 10.1155/2013/949513. Epub 2013 Feb 18.