PMID- 23478005
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20151119
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 209
IP  - 4
DP  - 2013 Apr
TI  - Classical Hodgkin lymphoma, lymphocyte depleted type: clinicopathological 
      analysis and prognostic comparison with other types of classical Hodgkin 
      lymphoma.
PG  - 201-7
LID - S0344-0338(12)00328-7 [pii]
LID - 10.1016/j.prp.2012.11.003 [doi]
AB  - The lymphocyte-depleted type (LD) is a morphological subtype of classical Hodgkin 
      lymphoma (CHL), but its rarity and heterogeneous morphological character makes a 
      definite clinicopathological identification difficult. To characterize this 
      disease, LD cases were compared with other types of CHL. From 1982 to 2006, we 
      collected 310 CHL cases. Among them, 29 cases were diagnosed as LD. We could 
      additionally analyze clinical data of 157 CHL cases (including 28 LD cases) and 
      the immunophenotype of 150 CHL cases (including 28 LD cases). We compared 
      clinicopathological data between LD cases and other types of CHL cases and 
      determined prognostic factors by univariate and multivariate analysis. LD showed 
      a more progressive disease stage (stage 3/4, 64%) than other types of CHL (stage 
      3/4, 30%; P<0.001), more frequent B symptoms (89% vs. 40%; P<0.001) and 
      extranodal invasion (50% vs. 11%; P<0.001), older age (median: 66 vs. 33; 
      P<0.001), higher serum soluble interleukin 2 receptor levels (median: 8240U/ml 
      vs. 1705U/ml; P<0.001), and much poorer prognosis regardless of the international 
      prognostic score (IPS) (five-year overall survival: 29% vs. 86%; P<0.001). The 
      morphological subtype of LD represented an independent prognostic factor as did 
      age and IPS by multivariate analysis. Immunohistochemistry showed that the 
      characteristics of Hodgkin and Reed-Sternberg (HRS) cells of LD are basically not 
      different from those of other types of CHL in terms of CD30, CD15, and chemokine 
      receptors, except for high-level EB-virus infection (72% vs. 41%; P=0.002). LD 
      should be distinguished from other types of classical Hodgkin lymphoma because of 
      its definitive clinicopathological characters.
CI  - Copyright (c) 2013 Elsevier GmbH. All rights reserved.
FAU - Karube, Kennosuke
AU  - Karube K
AD  - Department of Pathology, School of Medicine, Kurume University, Japan. 
      karube1975@aichi-cc.jp
FAU - Niino, Daisuke
AU  - Niino D
FAU - Kimura, Yoshizo
AU  - Kimura Y
FAU - Ohshima, Koichi
AU  - Ohshima K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130309
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Receptors, Interleukin-2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/blood
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hodgkin Disease/blood/classification/immunology/mortality/*pathology/therapy
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - Kaplan-Meier Estimate
MH  - Lymphocytes/immunology/*pathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Receptors, Interleukin-2/blood
MH  - Reed-Sternberg Cells/pathology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Young Adult
EDAT- 2013/03/13 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/03/13 06:00
PHST- 2012/09/10 00:00 [received]
PHST- 2012/11/05 00:00 [revised]
PHST- 2012/11/26 00:00 [accepted]
PHST- 2013/03/13 06:00 [entrez]
PHST- 2013/03/13 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - S0344-0338(12)00328-7 [pii]
AID - 10.1016/j.prp.2012.11.003 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2013 Apr;209(4):201-7. doi: 10.1016/j.prp.2012.11.003. Epub 
      2013 Mar 9.