PMID- 23478359
OWN - NLM
STAT- MEDLINE
DCOM- 20130606
LR  - 20201222
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 95
IP  - 8
DP  - 2013 Apr 27
TI  - KIR gene mismatching and KIR/C ligands in liver transplantation: consequences for 
      short-term liver allograft injury.
PG  - 1037-44
LID - 10.1097/TP.0b013e318286486c [doi]
AB  - BACKGROUND: Killer immunoglobulin-like receptors (KIRs) bind human leukocyte 
      antigen (HLA) class-I (HLA-I) ligands and regulate functions of natural killer 
      cells and subsets of T cells. KIR/HLA-I interactions allow predicting natural 
      killer cell alloreactivity in hematopoietic stem cell transplantation and in 
      HLA-compatible kidney transplants, but its meaning in liver transplantation 
      remains controversial. METHODS: KIR and HLA genotypes were studied in 402 liver 
      transplants, using sequence-specific oligonucleotides and primer methods. 
      Recipients and donor KIRs, HLA-C genotypes, KIR gene mismatches (MMs) between 
      recipient-donor pairs, and KIR/HLA-ligand combinations were analyzed in overall 
      transplantations, in the acute rejection (AR; n=110) and non-AR (n=292) groups. 
      RESULTS: KIR gene MMs between recipients and donors, mainly in activating KIRs, 
      and KIR2DL3 and KIR2DS1 of recipients in the presence of donor C2 ligands, 
      significantly enhanced early AR rate (P<0.05), with KIR2DL3 and KIR2DS1 
      exhibiting a synergic effect in dependence of the donor C2 ligand number 
      (chi2=7.662, P=0.022). KIR2DL3, KIR2DS1, and also KIR2DS4 significantly influenced 
      short-term graft survival, with a benefit for transplantations combining KIR2DL3 
      recipients and donors having C1 ligands (log rank, P<0.019 at 1 year; hazards 
      ratio [HR], 0.321; 95% confidence interval [CI], 0.107-0.962; P=0.042), whereas 
      KIR2DS1 and KIR2DS4 recipients combined with donors lacking C1 ligands (C2/C2) 
      exhibited a worse graft survival (log rank, P=0.035 at 6 months; HR, 7.713; 95% 
      CI, 2.156-27.369; P=0.002 for KIR2DS1; and log rank, P=0.006 at 1 year; HR, 
      3.794; 95% CI, 1.267-11.365; P=0.017 for KIR2DS4). CONCLUSIONS: This study shows 
      that KIR gene-gene MMs increase AR and that KIRs/C ligands associated to AR and 
      KIR2DS4/C ligands also influence short-term graft survival.
FAU - Legaz, Isabel
AU  - Legaz I
AD  - Immunology Service, Centro de Investigacion Biomedica en Red de Enfermedades 
      Hepaticas y Digestivas and Instituto Murciano de Investigacion Biomedica, Murcia, 
      Spain.
FAU - Lopez-Alvarez, Maria R
AU  - Lopez-Alvarez MR
FAU - Campillo, Jose A
AU  - Campillo JA
FAU - Moya-Quiles, Maria R
AU  - Moya-Quiles MR
FAU - Bolarin, Jose M
AU  - Bolarin JM
FAU - de la Pena, Jesus
AU  - de la Pena J
FAU - Salgado, Gema
AU  - Salgado G
FAU - Gimeno, Lourdes
AU  - Gimeno L
FAU - Garcia-Alonso, Ana M
AU  - Garcia-Alonso AM
FAU - Muro, Manuel
AU  - Muro M
FAU - Miras, Manuel
AU  - Miras M
FAU - Alonso, Clara
AU  - Alonso C
FAU - Alvarez-Lopez, Maria R
AU  - Alvarez-Lopez MR
FAU - Minguela, Alfredo
AU  - Minguela A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA-C Antigens)
RN  - 0 (KIR2DL3 protein, human)
RN  - 0 (KIR2DS1 protein, human)
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, KIR2DL3)
SB  - IM
MH  - Cohort Studies
MH  - Female
MH  - Graft Rejection/genetics/immunology
MH  - Graft Survival/genetics/immunology
MH  - HLA-C Antigens/metabolism
MH  - Hepatitis C/etiology/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Killer Cells, Natural/immunology
MH  - Ligands
MH  - Liver Transplantation/adverse effects/*immunology
MH  - Male
MH  - Middle Aged
MH  - Receptors, KIR/*genetics
MH  - Receptors, KIR2DL3/genetics
MH  - Recurrence
MH  - T-Lymphocyte Subsets/immunology
MH  - Time Factors
EDAT- 2013/03/13 06:00
MHDA- 2013/06/07 06:00
CRDT- 2013/03/13 06:00
PHST- 2013/03/13 06:00 [entrez]
PHST- 2013/03/13 06:00 [pubmed]
PHST- 2013/06/07 06:00 [medline]
AID - 10.1097/TP.0b013e318286486c [doi]
PST - ppublish
SO  - Transplantation. 2013 Apr 27;95(8):1037-44. doi: 10.1097/TP.0b013e318286486c.