PMID- 23478427
OWN - NLM
STAT- MEDLINE
DCOM- 20140812
LR  - 20221207
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 37
IP  - 12
DP  - 2013 Dec
TI  - Polymorphisms of matrix metalloproteinase gene and adiposity indices in European 
      children: results of the IDEFICS study.
PG  - 1539-44
LID - 10.1038/ijo.2013.21 [doi]
AB  - OBJECTIVE: We investigated the relationship between matrix metalloproteinase 3 
      (MMP3) polymorphisms and adiposity indices in European children of the IDEFICS 
      (Identification and Prevention of Dietary- and Lifestyle-Induced Health Effects 
      in Children and Infants) project. SUBJECTS: A total of 16 224 Caucasian children 
      (2-9 years) were recruited into a population-based survey from eight European 
      countries. In all, 4540 children were randomly selected for genetic studies (T0); 
      3238 children were re-examined 2 years later (T1). Anthropometric measures were 
      collected by standardized protocols at T0 and T1. RESULTS: Six variants of MMP3 
      gene were genotyped. Homozygotes for the variant A allele of rs646910 and for the 
      H3 haplotype had higher hip circumference (P=0.002 and 0.001; age, sex and 
      country adjusted) at T0. The association remained significant after false 
      discovery rate (FDR) correction. At T1, subjects carrying rs646910 A/A genotype 
      or H3/H3 diplotype showed significantly higher values of body mass index, waist 
      and hip circumference and sum of tricipital and subscapular skinfolds, all 
      associations remaining significant after FDR correction (P=0.020-0.048). 
      CONCLUSIONS: We showed for the first time an association between the MMP3 
      rs646910 variant and indices of adiposity in European children, highlighting the 
      involvement of metalloproteinase genes in adipose tissue remodeling and growth.
FAU - Cugino, D
AU  - Cugino D
AD  - Research Laboratories, Fondazione di Ricerca e Cura 'Giovanni Paolo II', 
      Universita Cattolica del Sacro Cuore, Campobasso, Italy.
FAU - Gianfagna, F
AU  - Gianfagna F
FAU - Ahrens, W
AU  - Ahrens W
FAU - De Henauw, S
AU  - De Henauw S
FAU - Koni, A C
AU  - Koni AC
FAU - Marild, S
AU  - Marild S
FAU - Molnar, D
AU  - Molnar D
FAU - Moreno, L A
AU  - Moreno LA
FAU - Pitsiladis, Y
AU  - Pitsiladis Y
FAU - Russo, P
AU  - Russo P
FAU - Siani, A
AU  - Siani A
FAU - Tornaritis, M
AU  - Tornaritis M
FAU - Veidebaum, T
AU  - Veidebaum T
FAU - Iacoviello, L
AU  - Iacoviello L
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20130312
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Adiposity/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Diet
MH  - Europe
MH  - Female
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - Humans
MH  - Life Style
MH  - Longitudinal Studies
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Predictive Value of Tests
MH  - White People/*genetics
EDAT- 2013/03/13 06:00
MHDA- 2014/08/13 06:00
CRDT- 2013/03/13 06:00
PHST- 2012/11/23 00:00 [received]
PHST- 2013/01/22 00:00 [revised]
PHST- 2013/01/27 00:00 [accepted]
PHST- 2013/03/13 06:00 [entrez]
PHST- 2013/03/13 06:00 [pubmed]
PHST- 2014/08/13 06:00 [medline]
AID - ijo201321 [pii]
AID - 10.1038/ijo.2013.21 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2013 Dec;37(12):1539-44. doi: 10.1038/ijo.2013.21. Epub 2013 
      Mar 12.