PMID- 23478632
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20130326
IS  - 1538-9235 (Electronic)
IS  - 1040-5488 (Linking)
VI  - 90
IP  - 4
DP  - 2013 Apr
TI  - Effect of lens care systems on the clinical performance of a contact lens.
PG  - 344-50
LID - 10.1097/OPX.0b013e318288e10c [doi]
AB  - PURPOSE: To evaluate subjective responses, rates of solution-induced corneal 
      staining (SICS), and corneal infiltrative events (CIEs) associated with a 
      silicone hydrogel when worn under a daily disposable (DD) or daily wear (DW) 
      modality. METHODS: Data were obtained from seven prospective clinical trials, 
      involving 283 subjects wearing Senofilcon A contact lenses (Johnson and Johnson 
      Vision Care, Jacksonville, FL). Four groups wore the contact lens on a DW basis 
      using multipurpose solutions (DW-MPS, n = 160), two groups using hydrogen 
      peroxide (DW-H2O2, n = 83), and one group as a DD (n = 40). Participants were 
      followed for 3 months using the same protocol. Subjective ratings were compared 
      between DD and DW groups using a linear mixed model. Rates of SICS and CIE were 
      calculated as the percent frequency of first events within the 3-month study. 
      Association of SICS and CIE with subjective responses was analyzed using a linear 
      mixed model. RESULTS: End-of-day comfort and dryness ratings were significantly 
      better for DD (8.5 +/- 1.7 and 8.6 +/- 1.7, respectively) compared with DW-H2O2 (7.7 
      +/- 1.8, p = 0.01; 7.6 +/- 1.9, p = 0.006, respectively) and DW-MPS (7.7 +/- 1.7, p = 
      0.004; 7.6 +/- 2.0, p = 0.003, respectively). Compared with DD, a higher incidence 
      of CIE and SICS was found for DW-MPS (0.0 vs. 3.9%, p = 0.021; 0.9 vs. 8.6%, p = 
      0.002, respectively). Comfort at insertion and end of day and end-of-day dryness 
      scores were significantly lower for participants who experienced SICS (8.2 +/- 1.6, 
      7.0 +/- 1.9, and 7.0 +/- 2.2) than those who did not (8.8 +/- 1.2, p = 0.004; 7.9 +/- 
      1.7, p = 0.002; and 7.9 +/- 1.8, p = 0.003, respectively). Comfort at insertion 
      scores were significantly lower for participants who experienced CIEs than those 
      who did not (8.2 +/- 1.5 vs. 8.8 +/- 1.4, p = 0.032). CONCLUSIONS: Senofilcon A 
      clinical response is modulated by the lens care products. All lens care products 
      tested reduced subjective responses relative to DD modality, whereas MPS 
      increased the incidence of CIEs and SICS. Senofilcon A performs best when used on 
      a DD basis.
FAU - Lazon de la Jara, Percy
AU  - Lazon de la Jara P
AD  - The Brien Holden Vision Institute, Sydney, New South Wales, Australia. 
      p.lazon@brienholdenvision.org
FAU - Papas, Eric
AU  - Papas E
FAU - Diec, Jennie
AU  - Diec J
FAU - Naduvilath, Thomas
AU  - Naduvilath T
FAU - Willcox, Mark D P
AU  - Willcox MD
FAU - Holden, Brien A
AU  - Holden BA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Optom Vis Sci
JT  - Optometry and vision science : official publication of the American Academy of 
      Optometry
JID - 8904931
RN  - 0 (Contact Lens Solutions)
SB  - IM
MH  - Adult
MH  - Contact Lens Solutions/*pharmacology/*standards
MH  - Contact Lenses/*standards
MH  - Cornea/*drug effects
MH  - Dry Eye Syndromes/epidemiology/*prevention & control
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - *Patient Satisfaction
MH  - Prospective Studies
MH  - Prosthesis-Related Infections/epidemiology/*prevention & control
EDAT- 2013/03/13 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/03/13 06:00
PHST- 2013/03/13 06:00 [entrez]
PHST- 2013/03/13 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - 10.1097/OPX.0b013e318288e10c [doi]
PST - ppublish
SO  - Optom Vis Sci. 2013 Apr;90(4):344-50. doi: 10.1097/OPX.0b013e318288e10c.