PMID- 23480298
OWN - NLM
STAT- MEDLINE
DCOM- 20140310
LR  - 20221207
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 5
IP  - 3
DP  - 2013 Sep
TI  - Association between glucose transporter 1 rs841853 polymorphism and type 2 
      diabetes mellitus risk may be population specific (1rs8418532).
PG  - 291-9
LID - 10.1111/1753-0407.12042 [doi]
AB  - BACKGROUND: So far, studies on the association between the glucose transporter 1 
      (GLUT1) rs841853 polymorphism and type 2 diabetes mellitus (T2DM) risk have 
      generated considerable controversy. The present study was performed to clarify 
      the association of this genetic variation with T2DM. METHODS: A comprehensive 
      literature search of electronic databases was conducted to obtain articles 
      focused on the relationship between the GLUT1 rs841853 polymorphism and T2DM, 
      followed by a systemic meta-analysis. RESULTS: Fourteen articles and 19 
      individual studies were included for analysis. Main analyses revealed extreme 
      heterogeneity and random effect pooled odds ratios (OR) were weakly significant 
      in allele contrast (OR 1.28; 95% confidence interval [CI] 1.01, 1.63; P=0.04) and 
      dominant model (OR 1.52; 95% CI 1.19, 1.94; P=0.0008) for T allele. Subgroup 
      analyses for Caucasians showed marginal positive results in the dominant model. 
      However, analyses for Asians yielded an obvious relationship to T2DM risk in all 
      genetic models. Interestingly, T allele even seemed to be a protective factor 
      against the development of T2DM in Blacks in allele contrast. Sensitivity 
      analyses did not alter materially for most comparisons and no publication bias 
      was found in this meta-analysis. CONCLUSIONS: The results of the present 
      meta-analysis provide evidence that the GLUT1 rs841853 polymorphism may confer 
      increased susceptibility to T2DM in Asians. However, there is no currently 
      available strong evidence supporting the association between this genetic 
      variation and T2DM in Caucasians, Blacks, or the overall population.
CI  - (c) 2013 Wiley Publishing Asia Pty Ltd and Ruijin Hospital, Shanghai Jiaotong 
      University School of Medicine.
FAU - Du, Bing
AU  - Du B
AD  - Second Division of the First Hospital, Jilin University, Changchun, China.
FAU - Liu, Shengmao
AU  - Liu S
FAU - Cui, Chengji
AU  - Cui C
FAU - Wang, Songyan
AU  - Wang S
FAU - Cui, Wenpeng
AU  - Cui W
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20130529
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Glucose Transporter Type 1)
RN  - 0 (SLC2A1 protein, human)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Black People/genetics
MH  - Diabetes Mellitus, Type 2/ethnology/*genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/ethnology/*genetics
MH  - Genotype
MH  - Glucose Transporter Type 1/*genetics
MH  - Humans
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - White People/genetics
OTO - NOTNLM
OT  - gene polymorphism
OT  - glucose transporter 1
OT  - meta-analysis
OT  - rs841853
OT  - type 2 diabetes mellitus
OT  - 基因多态性， 对葡萄糖转移酶1，Meta分析，rs841853，2型糖尿病
EDAT- 2013/03/14 06:00
MHDA- 2014/03/13 06:00
CRDT- 2013/03/14 06:00
PHST- 2013/01/25 00:00 [received]
PHST- 2013/02/27 00:00 [revised]
PHST- 2013/03/06 00:00 [accepted]
PHST- 2013/03/14 06:00 [entrez]
PHST- 2013/03/14 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
AID - 10.1111/1753-0407.12042 [doi]
PST - ppublish
SO  - J Diabetes. 2013 Sep;5(3):291-9. doi: 10.1111/1753-0407.12042. Epub 2013 May 29.