PMID- 23480432
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130314
LR  - 20140731
IS  - 1746-0441 (Print)
IS  - 1746-0441 (Linking)
VI  - 4
IP  - 11
DP  - 2009 Nov
TI  - In vitro and in vivo models of celiac disease.
PG  - 1113-23
LID - 10.1517/17460440903307417 [doi]
AB  - Background : Celiac disease is an autoimmune intestinal disease that develops in 
      genetically susceptible individuals upon the ingestion of gluten. In vitro and in 
      vivo models have addressed the roles of the following five elements in the 
      pathogenesis of celiac disease: i) A tight association with human leukocyte 
      antigen (HLA)-DQ2 and HLA-DQ8. ii) A strong B-cell response to the autoantigen 
      tissue transglutaminase that preferentially reacts with certain gluten peptides 
      and that is almost exclusively IgA. iii) An adaptive inflammatory immune response 
      to gluten peptides that are antigenically presented on HLA-DQ2 or HLA-DQ8. iv) An 
      improved antigenic presentation of most gluten peptides and a stronger T-cell 
      response after their deamidation by tissue transglutaminase; and v) An increased 
      risk for autoimmune diseases associated with celiac disease, such as dermatitis 
      herpetiformis and type 1 diabetes. OBJECTIVE: To summarize the different in vitro 
      and in vivo models of celiac disease, their contributions to our understanding of 
      the pathogenesis of celiac disease and the alternative therapies that have been 
      tested using these models. CONCLUSION: These models, especially the animal 
      models, are continuously being developed. They have contributed greatly to the 
      development of alternative therapies for celiac disease and are being used 
      increasingly to test their effectiveness and potential.
FAU - Marietta, Eric Vincent
AU  - Marietta EV
AD  - Mayo Clinic, Dermatology and Immunology, Guggenheim 10-02, Mayo Clinic Rochester, 
      Rochester, 55905, USA.
FAU - Schuppan, Detlef
AU  - Schuppan D
FAU - Murray, Joseph A
AU  - Murray JA
LA  - eng
PT  - Journal Article
DEP - 20091006
PL  - England
TA  - Expert Opin Drug Discov
JT  - Expert opinion on drug discovery
JID - 101295755
EDAT- 2009/11/01 00:00
MHDA- 2009/11/01 00:01
CRDT- 2013/03/14 06:00
PHST- 2013/03/14 06:00 [entrez]
PHST- 2009/11/01 00:00 [pubmed]
PHST- 2009/11/01 00:01 [medline]
AID - 10.1517/17460440903307417 [doi]
PST - ppublish
SO  - Expert Opin Drug Discov. 2009 Nov;4(11):1113-23. doi: 10.1517/17460440903307417. 
      Epub 2009 Oct 6.