PMID- 23480770
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20181202
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 13 Suppl
DP  - 2012
TI  - Aberrant expression of CD44 in bile duct cancer correlates with poor prognosis.
PG  - 95-9
AB  - CCD44, a transmembrane glycoprotein receptor, plays significant roles in cell 
      migration, differentiation, and survival signaling which are important for both 
      normal and cancer cells. In this study, we examined the expression of all 
      isoforms of CD44 by immunohistochemistry in 3 cases of biliary cystadenoma, 15 
      cases of non-invasive cystadenocarcinoma (CAC) bile duct tumors, and 67 cases of 
      the aggressive bile duct tumor, cholangiocarcinoma (CCA). Normal bile duct 
      epithelia at different segments along the biliary tree did not express CD44. 
      However, normal biliary cells of the large bile duct adjacent to tumor areas and 
      dysplastic biliary cells in CCA tissues were positive. CD44 was not expressed in 
      cystadenomas and the majority of CACs. Two CAC cases with short survival and the 
      majority of CCA aberrantly expressed CD44. These observations suggest important 
      roles for CD44 in the early stage of carcinogenesis and progression of bile duct 
      cancer. Regardless of the type of bile duct tumor, CAC or CCA patients with 
      positive CD44 expression in biliary epithelia had significant shorter survival 
      than those with negative CD44. Aberrant expression of CD44 in CAC or CCA tissues 
      may indicate an unfavorable patient outcome and may serve as a useful practical 
      adjunct to conventional prognostic indicators for bile duct cancer.
FAU - Kunlabut, Kunlathida
AU  - Kunlabut K
AD  - Department of Biochemistry, Khon Kaen University, Khon Kaen, Thailand.
FAU - Vaeteewoottacharn, Kulthida
AU  - Vaeteewoottacharn K
FAU - Wongkham, Chaisiri
AU  - Wongkham C
FAU - Khuntikeo, Narong
AU  - Khuntikeo N
FAU - Waraasawapati, Sakda
AU  - Waraasawapati S
FAU - Pairojkul, Chawalit
AU  - Pairojkul C
FAU - Wongkham, Sopit
AU  - Wongkham S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - *Bile Duct Neoplasms
MH  - *Bile Ducts, Intrahepatic
MH  - Cholangiocarcinoma
MH  - Cystadenocarcinoma
MH  - Humans
MH  - Prognosis
EDAT- 2012/01/01 00:00
MHDA- 2016/04/23 06:00
CRDT- 2013/03/14 06:00
PHST- 2013/03/14 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 27152 [pii]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2012;13 Suppl:95-9.