PMID- 23480773
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20181202
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 13 Suppl
DP  - 2012
TI  - Impaired antioxidant enzyme activity and increased DNA repair enzyme expression 
      in hamster liver tissues related to cholangiocarcinoma development.
PG  - 59-64
AB  - A possible mechanism of liver fluke (Opisthorchis viverrini; Ov) -associated 
      cholangiocarcinoma (CCA) genesis may be imbalance in responses of antioxidant 
      enzymes and/or DNA repair enzymes which are the consequence of 
      oxidative/nitrative stress, arising from inflammatory processes. This study aimed 
      to investigate changes in the expression patterns of antioxidant enzymes, 
      including superoxide dismutase 2 (SOD2) and catalase (CAT), as well as their 
      activities in Ov-associated hamster CCA tissues. Expression of DNA repair enzymes 
      including apurinic endonuclease (APE) and DNA polymerase beta (DNA pol beta) was 
      also investigated. Our results showed that SOD2 and CAT levels were increased in 
      CCA-induced liver hamster tissues at every time point during 
      cholangiocarcinogenesis. However, once tumors were well established, activities 
      of both enzymes were significantly decreased. Expression of APE and DNA pol beta was 
      increased in the acute phase of Ov infection and this persisted until tumors 
      developed. These findings suggest that a reduction in antioxidant enzymes and an 
      increase in DNA repair enzymes may contribute to DNA translesion-mediated CCA in 
      liver fluke-associated cholangiocarcinogenesis in the hamster model.
FAU - Loilome, Watcharin
AU  - Loilome W
AD  - Department of Biochemistry, Khon Kaen University, Khon Kaen, Thailand.
FAU - Kadsanit, Sasithorn
AU  - Kadsanit S
FAU - Namwat, Nisana
AU  - Namwat N
FAU - Techasen, Anchalee
AU  - Techasen A
FAU - Puapairoj, Anucha
AU  - Puapairoj A
FAU - Dechakhamphu, Ananya
AU  - Dechakhamphu A
FAU - Pinitsoontorn, Chadamas
AU  - Pinitsoontorn C
FAU - Yongvanit, Puangrat
AU  - Yongvanit P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Animals
MH  - *Bile Duct Neoplasms
MH  - Bile Ducts, Intrahepatic
MH  - Cholangiocarcinoma
MH  - Cricetinae
MH  - Liver/metabolism
MH  - Mesocricetus
MH  - *Opisthorchiasis/genetics
MH  - Opisthorchis
EDAT- 2012/01/01 00:00
MHDA- 2016/04/23 06:00
CRDT- 2013/03/14 06:00
PHST- 2013/03/14 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 27146 [pii]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2012;13 Suppl:59-64.