PMID- 23482249
OWN - NLM
STAT- MEDLINE
DCOM- 20131206
LR  - 20211021
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 19
IP  - 8
DP  - 2013 Feb 28
TI  - Multiple endocrine neoplasia type 1 with upper gastrointestinal hemorrhage and 
      perforation: a case report and review.
PG  - 1322-6
LID - 10.3748/wjg.v19.i8.1322 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary syndrome known to 
      predispose subjects to endocrine neoplasms in a variety of tissues such as the 
      parathyroid glands, pituitary gland, pancreas and gastrointestinal tract. We 
      herein report a patient with a past history of pituitary adenoma, presenting with 
      symptoms of chronic diarrhea for nearly one year and a sudden upper 
      gastrointestinal hemorrhage as well as perforation without signs. Nodules in the 
      duodenum and in the uncinate process and tail of pancreas and enlargement of the 
      parathyroid glands were detected on preoperative imaging. Gastroscopy revealed 
      significant ulceration and esophageal reflux diseases. The patient underwent 
      subtotal parathyroidectomy and autotransplantation, pylorus-preserving 
      pancreaticoduodenectomy and pancreatic tail resection and recovered well. The 
      results observed in our patient suggest that perforation and bleeding of 
      intestine might be symptoms of Zollinger-Ellison Syndrome in patients with MEN1.
FAU - Lu, Ying-Ying
AU  - Lu YY
AD  - Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao 
      Tong University School of Medicine, Shanghai 200080, China.
FAU - Zhu, Feng
AU  - Zhu F
FAU - Jing, Da-Dao
AU  - Jing DD
FAU - Wu, Xie-Ning
AU  - Wu XN
FAU - Lu, Lun-Gen
AU  - Lu LG
FAU - Zhou, Gen-Quan
AU  - Zhou GQ
FAU - Wang, Xing-Peng
AU  - Wang XP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Duodenal Diseases/diagnosis/*etiology/surgery
MH  - Gastrointestinal Hemorrhage/diagnosis/*etiology/surgery
MH  - Gastroscopy
MH  - Humans
MH  - Intestinal Perforation/diagnosis/*etiology/surgery
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/*complications/diagnosis
MH  - Pancreatectomy
MH  - Pancreaticoduodenectomy
MH  - Parathyroidectomy
MH  - Predictive Value of Tests
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - Zollinger-Ellison Syndrome/diagnosis/*etiology/surgery
PMC - PMC3587492
OTO - NOTNLM
OT  - Gastrinoma
OT  - Gastrointestinal hemorrhage
OT  - Hyperparathyroidism
OT  - Perforation
OT  - Pituitary adenoma
EDAT- 2013/03/14 06:00
MHDA- 2013/12/16 06:00
PMCR- 2013/02/28
CRDT- 2013/03/14 06:00
PHST- 2012/11/11 00:00 [received]
PHST- 2013/01/09 00:00 [revised]
PHST- 2013/01/23 00:00 [accepted]
PHST- 2013/03/14 06:00 [entrez]
PHST- 2013/03/14 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2013/02/28 00:00 [pmc-release]
AID - 10.3748/wjg.v19.i8.1322 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2013 Feb 28;19(8):1322-6. doi: 10.3748/wjg.v19.i8.1322.