PMID- 23482616
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130314
LR  - 20211021
IS  - 1000-9604 (Print)
IS  - 1993-0631 (Electronic)
IS  - 1000-9604 (Linking)
VI  - 23
IP  - 2
DP  - 2011 Jun
TI  - Clinical Impact of t(14;18) in Diffuse Large B-cell Lymphoma.
PG  - 160-4
LID - 10.1007/s11670-011-0160-x [doi]
AB  - OBJECTIVE: Recent studies have suggested that t(14;18) is present in a 
      significant proportion of diffuse large B-cell lymphomas (DLBCLs). However, the 
      prognostic significance of this translocation and its relationship with BCL-2 
      protein expression remains controversial. Our study aimed to investigate the 
      predictive power of t(14;18) and BCL-2 protein expression in the prognosis of 
      DLBCLs. METHODS: Biopsy specimens from 106 DLBCLs were analyzed using interphase 
      fluorescence in situ hybridization (FISH). Immunophenotypic analysis of CD20, 
      CD3, CD10, BCL-6, MUM1 and BCL-2 was performed by immunohistochemistry. SPSS 13.0 
      software was used for statistical analysis. RESULTS: The t(14;18) was identified 
      in 27 of 106 cases (25.5%). The percentages of tumor cells expressing CD10, 
      BCL-6, MUM1 and BCL-2 were 21.7%, 26.4%, 56.6% and 73.6%, respectively. The 
      presence of this translocation was significantly correlated with the expression 
      of CD10 and immunophenotypic subtype (p<0.001). No association was observed 
      between BCL-2 protein expression and the presence of t(14;18). Multivariate 
      analysis confirmed that both t(14;18) and BCL-2 expression were significantly 
      associated with survival. Moreover, patients with t(14;18) had worse prognosis, 
      compared with those with BCL-2 expression (for overall survival: hazard ratio, 
      4.235; 95%CI, 2.153-8.329, p<0.001 vs. hazard ration, 2.743; 95%CI, 1.262-5.962, 
      p=0.011). CONCLUSIONS: The t(14;18) is a useful prognostic tool for the 
      evaluation of DLBCL immunophenotype and prognosis. The prognosis of GCB (germinal 
      centre-like B cell) DLBCL patients should be made with the consideration of the 
      presence of this translocation, and the detection of t(14;18) should be included 
      as a routine diagnostic test in these cases.
FAU - Zhang, Hong-Wei
AU  - Zhang HW
AD  - Department of Biochemistry and Molecular Biology, Shanxi Medical University, 
      Taiyuan 030013, China;
FAU - Cheng, Niu-Liang
AU  - Cheng NL
FAU - Chen, Zhen-Wen
AU  - Chen ZW
FAU - Wang, Jin-Fen
AU  - Wang JF
FAU - Li, Su-Hong
AU  - Li SH
FAU - Bai, Wei
AU  - Bai W
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin J Cancer Res
JT  - Chinese journal of cancer research = Chung-kuo yen cheng yen chiu
JID - 9315242
PMC - PMC3587538
OTO - NOTNLM
OT  - 18), FISH, Survival analysis, Diffuse large B-cell lymphoma
OT  - Chromosome translocation, t(14
EDAT- 2011/06/01 00:00
MHDA- 2011/06/01 00:01
PMCR- 2011/06/01
CRDT- 2013/03/14 06:00
PHST- 2010/12/14 00:00 [received]
PHST- 2011/03/17 00:00 [accepted]
PHST- 2013/03/14 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2011/06/01 00:01 [medline]
PHST- 2011/06/01 00:00 [pmc-release]
AID - cjcr-23-02-160 [pii]
AID - 10.1007/s11670-011-0160-x [doi]
PST - ppublish
SO  - Chin J Cancer Res. 2011 Jun;23(2):160-4. doi: 10.1007/s11670-011-0160-x.