PMID- 23482723
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130314
LR  - 20211021
IS  - 1738-3684 (Print)
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Linking)
VI  - 10
IP  - 1
DP  - 2013 Mar
TI  - Association between the BDNF Val66Met Polymorphism and Chronicity of Depression.
PG  - 56-61
LID - 10.4306/pi.2013.10.1.56 [doi]
AB  - OBJECTIVE: Both clinical and biological factors influence the course of 
      depressive disorders. This study tested for associations between the 
      brain-derived neurotrophic factor (BDNF) gene at the Val66Met locus and the 
      course of major depressive disorder (MDD). METHODS: Three hundred ten Korean 
      subjects (209 patients, 101 controls) were genotyped for rs6265 at nucleotide 196 
      (G/A), which produces an amino acid substitution at codon 66 (Val66Met) of the 
      gene for BDNF. Course of illness was evaluated both by chronicity of current 
      episode (episode duration >24 months) and by the lifetime history of recurrences. 
      RESULTS: Patients with the Met/Met BDNF genotype had a significantly higher rate 
      of chronic depression than all others. There was a significant dose effect of the 
      Met allele on chronicity. Compared with the Val/Val genotype, the relative risk 
      of chronicity was 1.67 for the Val/Met genotype, and 2.58 for the Met/Met 
      genotype. Lifetime history of recurrent episodes was not related to BDNF 
      genotypes but was significantly associated with younger age of onset and with a 
      history of depression in first degree relatives. CONCLUSION: BDNF genotyping may 
      be informative for anticipating chronicity in major depression.
FAU - Lee, Yujin
AU  - Lee Y
AD  - Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Republic of Korea.
FAU - Lim, Shinn Won
AU  - Lim SW
FAU - Kim, Soo Yeon
AU  - Kim SY
FAU - Chung, Jae Won
AU  - Chung JW
FAU - Kim, Jinwoo
AU  - Kim J
FAU - Myung, Woojae
AU  - Myung W
FAU - Song, Jihae
AU  - Song J
FAU - Kim, Seonwoo
AU  - Kim S
FAU - Carroll, Bernard J
AU  - Carroll BJ
FAU - Kim, Doh Kwan
AU  - Kim DK
LA  - eng
PT  - Journal Article
DEP - 20130124
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC3590431
OTO - NOTNLM
OT  - BDNF Val66Met
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Chronicity
OT  - Clinical course
OT  - Major depressive disorder
OT  - Recurrent depression
EDAT- 2013/03/14 06:00
MHDA- 2013/03/14 06:01
PMCR- 2013/03/01
CRDT- 2013/03/14 06:00
PHST- 2012/06/18 00:00 [received]
PHST- 2012/07/16 00:00 [revised]
PHST- 2012/07/30 00:00 [accepted]
PHST- 2013/03/14 06:00 [entrez]
PHST- 2013/03/14 06:00 [pubmed]
PHST- 2013/03/14 06:01 [medline]
PHST- 2013/03/01 00:00 [pmc-release]
AID - 10.4306/pi.2013.10.1.56 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2013 Mar;10(1):56-61. doi: 10.4306/pi.2013.10.1.56. Epub 
      2013 Jan 24.