PMID- 23482768
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20211203
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 33
IP  - 3
DP  - 2013 Mar
TI  - Expression of metallothionein-III in patients with non-small cell lung cancer.
PG  - 965-74
AB  - BACKGROUND: Currently, there is little knowledge concerning expression of 
      metallothionein-III (MT-III), also known as growth-inhibitory factor, in 
      non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: In this study, we 
      evaluated MT-III expression in 184 patients using immunohistochemistry and in 61 
      cases using real-time polymerase chain reaction. RESULTS: MT-III mRNA expression 
      was significantly higher in NSCLC as compared to non-malignant lung tissues 
      (NMLT; p<0.0086). MT-III expression was noted in the cytoplasm and nucleus of 
      cancer cells. Significantly lower nuclear MT-III (p<0.0001) expression and 
      significantly higher cytoplasmic MT-III (p=0.0068) expression was noted in the 
      pneumocytes of NMLT, as compared to NSCLC. Nuclear MT-III expression was 
      significantly higher in G1 cases as compared to G2 (p=0.0308) and G3 (p=0.0194) 
      cases. Low cytoplasmic MT-III expression was associated with larger primary 
      tumour size (p=0.0378). Lower MT-III mRNA and cytoplasmic MT-III expression was 
      associated with poor patient outcome (p=0.0410 and p=0.0347, respectively). 
      CONCLUSION: MT-III expression may have an impact on the pathogenesis of NSCLC.
FAU - Werynska, Bozena
AU  - Werynska B
AD  - Department of Histology and Embryology, Wroclaw Medical University, 
      Chalubinskiego 6a, 50-368 Wroclaw, Poland. piotr.dziegiel@umed.wroc.pl
FAU - Pula, Bartosz
AU  - Pula B
FAU - Muszczynska-Bernhard, Beata
AU  - Muszczynska-Bernhard B
FAU - Gomulkiewicz, Agnieszka
AU  - Gomulkiewicz A
FAU - Jethon, Aleksandra
AU  - Jethon A
FAU - Podhorska-Okolow, Marzena
AU  - Podhorska-Okolow M
FAU - Jankowska, Renata
AU  - Jankowska R
FAU - Dziegiel, Piotr
AU  - Dziegiel P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Metallothionein 3)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Non-Small-Cell Lung/*etiology/metabolism/pathology
MH  - Cell Nucleus/chemistry
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Lung Neoplasms/*etiology/metabolism/pathology
MH  - Male
MH  - Metallothionein 3
MH  - Middle Aged
MH  - Nerve Tissue Proteins/analysis/genetics/*physiology
MH  - RNA, Messenger/analysis
EDAT- 2013/03/14 06:00
MHDA- 2013/05/17 06:00
CRDT- 2013/03/14 06:00
PHST- 2013/03/14 06:00 [entrez]
PHST- 2013/03/14 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - 33/3/965 [pii]
PST - ppublish
SO  - Anticancer Res. 2013 Mar;33(3):965-74.