PMID- 23483204
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130314
LR  - 20211021
IS  - 1738-1843 (Print)
IS  - 2092-8920 (Electronic)
IS  - 1738-1843 (Linking)
VI  - 47
IP  - 1
DP  - 2013 Feb
TI  - Finding and characterizing mammary analogue secretory carcinoma of the salivary 
      gland.
PG  - 36-43
LID - 10.4132/KoreanJPathol.2013.47.1.36 [doi]
AB  - BACKGROUND: A new tumor entity of the salivary glands, mammary analogue secretory 
      carcinoma (MASC) with ETV6-NTRK3 translocation, has recently been proposed. MASC 
      was originally diagnosed as adenocarcinoma, not otherwise specified (ANOS), or 
      acinic cell carcinoma (AciCC) by the current World Health Organization 
      classification. We aimed to identify MASC cases by molecular tests, and to 
      characterize their clinical, histological, and immunohistochemical features. 
      METHODS: Thirty cases of MASC candidates were selected after review of 196 
      salivary gland tumors, and subjected to break-apart ETV6 fluorescence in situ 
      hybridization (FISH), and immunohistochemical study for S100 protein, gross 
      cystic disease fluid protein 15, DOG1, estrogen receptor, and progesterone 
      receptor. RESULTS: Valid FISH results were obtained in 23 cases, and 13 positive 
      cases were retrieved. MASCs were histologically varied, and the most frequent 
      features observed in 10 cases were low-grade papillary/cystic/glandular patterns, 
      intraluminal secretory materials, ovoid/wrinkled nuclei, and relatively abundant 
      granular eosinophilic cytoplasms, corresponding to papillary-cystic or follicular 
      types of AciCC. All cases showed diffuse immunopositivity for S100 protein. Three 
      cases developed recurrences, but all patients remained alive. CONCLUSIONS: MASC 
      could be a molecularly well-defined salivary gland neoplasm, encompassing some 
      portions of AciCC and ANOS, but its histological spectrum and clinical 
      implication require further investigation.
FAU - Jung, Min Jung
AU  - Jung MJ
AD  - Department of Pathology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Korea.
FAU - Song, Joon Seon
AU  - Song JS
FAU - Kim, Sang Yoon
AU  - Kim SY
FAU - Nam, Soon Yuhl
AU  - Nam SY
FAU - Roh, Jong-Lyel
AU  - Roh JL
FAU - Choi, Seung-Ho
AU  - Choi SH
FAU - Kim, Sung-Bae
AU  - Kim SB
FAU - Cho, Kyung-Ja
AU  - Cho KJ
LA  - eng
PT  - Journal Article
DEP - 20130225
PL  - Korea (South)
TA  - Korean J Pathol
JT  - Korean journal of pathology
JID - 101275976
PMC - PMC3589607
OTO - NOTNLM
OT  - Carcinoma, acinar cell
OT  - ETV6-NTRK3 fusion protein, human
OT  - In situ hybridization, fluorescence
OT  - Salivary gland neoplasms
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2013/03/14 06:00
MHDA- 2013/03/14 06:01
PMCR- 2013/02/01
CRDT- 2013/03/14 06:00
PHST- 2012/12/13 00:00 [received]
PHST- 2013/01/08 00:00 [revised]
PHST- 2013/01/09 00:00 [accepted]
PHST- 2013/03/14 06:00 [entrez]
PHST- 2013/03/14 06:00 [pubmed]
PHST- 2013/03/14 06:01 [medline]
PHST- 2013/02/01 00:00 [pmc-release]
AID - 10.4132/KoreanJPathol.2013.47.1.36 [doi]
PST - ppublish
SO  - Korean J Pathol. 2013 Feb;47(1):36-43. doi: 10.4132/KoreanJPathol.2013.47.1.36. 
      Epub 2013 Feb 25.