PMID- 23483353
OWN - NLM
STAT- MEDLINE
DCOM- 20140204
LR  - 20211021
IS  - 1573-4994 (Electronic)
IS  - 1053-0509 (Linking)
VI  - 23
IP  - 4
DP  - 2013 Jul
TI  - Spectrofluorimetric determination of fluoroquinolones in honey with 
      2,3-dichloro-5,6-dicyano-1,4-benzoquinone in the presence of beta-cyclodextrin.
PG  - 713-23
LID - 10.1007/s10895-013-1166-1 [doi]
AB  - A simple and sensitive spectrofluorimetric method was developed for the 
      determination of four fluoroquinolone antibacterials namely norfloxacin (NOR), 
      ofloxacin (OFL), ciprofloxacin (CIP) and gatifloxacin (GAT) in honey through 
      charge transfer (CT) complex formation with 
      2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), and then the inclusion complexes 
      of FQs-DDQ with beta-cyclodextrin (beta-CD) were formed, which resulted in drastic 
      fluorescence enhancement. The effect of several parameters including the 
      concentration of reactants, reaction temperature, time and ultrasonic treatment 
      on the efficiency of the proposed method involving CT reaction and inclusion 
      interaction was systematically investigated. Under the optimum conditions, the 
      limits of detection (LODs) for four FQs in honey varied from 11.6 to 15.4 mug/kg 
      (signal-to-noise ratio (S/N) = 3). The intra- and interday relative standard 
      deviations (RSDs) were 1.6-4.0 % (n = 5) for four FQs. The calibration graph was 
      linear from 42.8 to 1346.8 mug/kg with correlation coefficients not less than 
      0.9905. The recoveries of four FQs at three different spiked concentrations in 
      honey samples ranged from 80.9 % to 92.8 %. The results indicated that the method 
      was successfully applied for analyzing FQs in honey.
FAU - Xia, Qinghai
AU  - Xia Q
AD  - Faculty of Environmental Science and Engineering, Kunming University of Science 
      and Technology, Kunming, 650500, People's Republic of China.
FAU - Yang, Yaling
AU  - Yang Y
FAU - Liu, Mousheng
AU  - Liu M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130313
PL  - Netherlands
TA  - J Fluoresc
JT  - Journal of fluorescence
JID - 9201341
RN  - 0 (Benzoquinones)
RN  - 0 (Fluoroquinolones)
RN  - 0 (beta-Cyclodextrins)
RN  - 1H5KD39UH7 (dichlorodicyanobenzoquinone)
SB  - IM
MH  - Benzoquinones/*chemistry
MH  - Drug Residues/analysis/chemistry
MH  - Electron Transport
MH  - Fluoroquinolones/*analysis/*chemistry
MH  - Honey/*analysis
MH  - Linear Models
MH  - Spectrometry, Fluorescence
MH  - Temperature
MH  - Time Factors
MH  - Ultrasonics
MH  - beta-Cyclodextrins/*chemistry
EDAT- 2013/03/14 06:00
MHDA- 2014/02/05 06:00
CRDT- 2013/03/14 06:00
PHST- 2012/08/25 00:00 [received]
PHST- 2013/01/31 00:00 [accepted]
PHST- 2013/03/14 06:00 [entrez]
PHST- 2013/03/14 06:00 [pubmed]
PHST- 2014/02/05 06:00 [medline]
AID - 10.1007/s10895-013-1166-1 [doi]
PST - ppublish
SO  - J Fluoresc. 2013 Jul;23(4):713-23. doi: 10.1007/s10895-013-1166-1. Epub 2013 Mar 
      13.