PMID- 23484910
OWN - NLM
STAT- MEDLINE
DCOM- 20140728
LR  - 20151119
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 23
IP  - 12
DP  - 2013 Dec
TI  - Mediterranean diet and non enzymatic antioxidant capacity in the PREDIMED study: 
      evidence for a mechanism of antioxidant tuning.
PG  - 1167-74
LID - S0939-4753(13)00003-3 [pii]
LID - 10.1016/j.numecd.2012.12.008 [doi]
AB  - BACKGROUND AND AIMS: The intake of antioxidant-rich foods may increase the blood 
      levels of non enzymatic antioxidant capacity (NEAC). NEAC takes into account all 
      antioxidants from food and synergistic effects between them. We examined the 
      effect of a 1-year intervention with Mediterranean diet on plasma NEAC and 
      assessed whether it was related to baseline NEAC levels. METHODS AND RESULTS: 
      Five hundred sixty-four participants at high cardiovascular risk were randomly 
      selected from the PREDIMED (Prevencion con DIeta MEDiterranea) Study, a large 
      3-arm randomized clinical trial. Blood NEAC levels were measured at baseline and 
      after 1-year of dietary intervention with 1) a Mediterranean diet supplemented 
      with virgin olive oil (MED + VOO); 2) a Mediterranean diet supplemented with nuts 
      (MED + nuts), or 3) a control low-fat diet. Plasma NEAC was analyzed using FRAP 
      (ferric reducing antioxidant potential) and TRAP (total radical-trapping 
      antioxidant parameter) assays. Plasma FRAP levels increased after 1-year of 
      intervention with MED + VOO [72.0 mumol/L (95% CI, 34.2-109.9)] and MED + nuts 
      [48.9 mumol/L (24.3-73.5)], but not after the control low-fat diet [13.9 mumol/L 
      (-11.9 to 39.8)]. Participants in the lowest quartile of plasma FRAP at baseline 
      significantly increased their levels after any intervention, while those in the 
      highest quartile decreased. Similar results occurred with TRAP levels. 
      CONCLUSIONS: This study shows that a 1-year of MED diet intervention increases 
      plasma TAC level in subjects at high risk for cardiovascular disease. Moreover, 
      the effectiveness of dietary supplementation with antioxidants may be related to 
      baseline levels of plasma NEAC.
CI  - (c) 2013 Elsevier B.V. All rights reserved.
FAU - Zamora-Ros, R
AU  - Zamora-Ros R
AD  - Nutrition and Food Science Department, XaRTA INSA, Pharmacy School, University of 
      Barcelona, Av/Joan XXIII s/n, 08028 Barcelona, Spain; Unit of Nutrition, 
      Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute 
      of Oncology (ICO-IDIBELL), Barcelona, Spain.
FAU - Serafini, M
AU  - Serafini M
FAU - Estruch, R
AU  - Estruch R
FAU - Lamuela-Raventos, R M
AU  - Lamuela-Raventos RM
FAU - Martinez-Gonzalez, M A
AU  - Martinez-Gonzalez MA
FAU - Salas-Salvado, J
AU  - Salas-Salvado J
FAU - Fiol, M
AU  - Fiol M
FAU - Lapetra, J
AU  - Lapetra J
FAU - Aros, F
AU  - Aros F
FAU - Covas, M I
AU  - Covas MI
FAU - Andres-Lacueva, C
AU  - Andres-Lacueva C
CN  - PREDIMED Study Investigators
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130226
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Antioxidants)
RN  - 0 (Olive Oil)
RN  - 0 (Plant Oils)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antioxidants/*administration & dosage/metabolism
MH  - Cardiovascular Diseases/diet therapy/*prevention & control
MH  - Diet, Fat-Restricted
MH  - *Diet, Mediterranean
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nuts
MH  - Olive Oil
MH  - Plant Oils/administration & dosage
MH  - Risk Factors
OTO - NOTNLM
OT  - CVD
OT  - Dietary modulation
OT  - FRAP
OT  - MED
OT  - Mediterranean diet
OT  - NEAC
OT  - Non enzymatic antioxidant capacity
OT  - Oxidative stress
OT  - PREDIMED
OT  - Prevencion con Dieta Mediterranea
OT  - RONS
OT  - TRAP
OT  - Total antioxidant capacity
OT  - VOO
OT  - cardiovascular diseases
OT  - ferric reducing antioxidant potential
OT  - non enzymatic antioxidant capacity
OT  - reactive oxygen nitrogen species
OT  - total radical-trapping antioxidant parameter
OT  - virgin olive oil
FIR - Llorach, Rafael
IR  - Llorach R
FIR - Rabassa, Montserrat
IR  - Rabassa M
FIR - Medina-Remon, Alex
IR  - Medina-Remon A
FIR - Sacanella, Emilio
IR  - Sacanella E
FIR - Masanes, Ferran
IR  - Masanes F
FIR - Casas, Rosa
IR  - Casas R
FIR - Vinas, Concha
IR  - Vinas C
FIR - Extremera, Vicente
IR  - Extremera V
FIR - Arroyo, Concepcion
IR  - Arroyo C
FIR - Garcia Perez, Luisa
IR  - Garcia Perez L
FIR - Buil-Cosiales, Pilar
IR  - Buil-Cosiales P
FIR - Bullo, Monica
IR  - Bullo M
FIR - Babio, Nancy
IR  - Babio N
FIR - Basora, Josep
IR  - Basora J
FIR - Fito, Montse
IR  - Fito M
FIR - de la Torre, Rafael
IR  - de la Torre R
FIR - Schroder, Helmut
IR  - Schroder H
FIR - Santos, Jose Manuel
IR  - Santos JM
FIR - Ortega-Calvo, Manuel
IR  - Ortega-Calvo M
FIR - Garcia, Francisco Jose
IR  - Garcia FJ
FIR - Roman, Pilar
IR  - Roman P
EDAT- 2013/03/15 06:00
MHDA- 2014/07/30 06:00
CRDT- 2013/03/15 06:00
PHST- 2012/07/21 00:00 [received]
PHST- 2012/11/23 00:00 [revised]
PHST- 2012/12/27 00:00 [accepted]
PHST- 2013/03/15 06:00 [entrez]
PHST- 2013/03/15 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
AID - S0939-4753(13)00003-3 [pii]
AID - 10.1016/j.numecd.2012.12.008 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2013 Dec;23(12):1167-74. doi: 
      10.1016/j.numecd.2012.12.008. Epub 2013 Feb 26.