PMID- 23485718
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130317
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 3
IP  - 3
DP  - 2013 Mar 13
TI  - Development and validation of a brief screening instrument for psychosocial risk 
      associated with genetic testing: a pan-Canadian cohort study.
LID - 10.1136/bmjopen-2012-002227 [doi]
LID - e002227
AB  - OBJECTIVES: To develop a brief, reliable and valid instrument to screen 
      psychosocial risk among those who are undergoing genetic testing for Adult-Onset 
      Hereditary Disease (AOHD). DESIGN: A prospective two-phase cohort study. SETTING: 
      5 genetic testing centres for AOHD, such as cancer, Huntington's disease or 
      haemochromatosis, in ambulatory clinics of tertiary hospitals across Canada. 
      PARTICIPANTS: 141 individuals undergoing genetic testing were approached and 
      consented to the instrument development phase of the study (Phase I). The Genetic 
      Psychosocial Risk Instrument (GPRI) developed in Phase I was tested in Phase II 
      for item refinement and validation. A separate cohort of 722 individuals 
      consented to the study, 712 completed the baseline package and 463 completed all 
      follow-up assessments. Most participants were female, at the mid-life stage. 
      Individuals in advanced stages of the illness or with cognitive impairment or a 
      language barrier were excluded. INTERVENTIONS: Phase I: GPRI items were generated 
      from (1) a review of the literature, (2) input from genetic counsellors and (3) 
      phase I participants. Phase II: further item refinement and validation were 
      conducted with a second cohort of participants who completed the GPRI at baseline 
      and were followed for psychological distress 1-month postgenetic testing results. 
      PRIMARY AND SECONDARY OUTCOME MEASURES: GPRI, Hamilton Depression Rating Scale 
      (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), Brief Symptom Inventory (BSI) and 
      Impact of Event Scale (IES). RESULTS: The final 20-item GPRI had a high 
      reliability-Cronbach's alpha at 0.81. The construct validity was supported by high 
      correlations between GPRI and BSI and IES. The predictive value was demonstrated 
      by a receiver operating characteristic curve of 0.78 plotting GPRI against 
      follow-up assessments using HAM-D and HAM-A. CONCLUSIONS: With a cut-off score of 
      50, GPRI identified 84% of participants who displayed distress postgenetic 
      testing results, supporting its potential usefulness in a clinical setting.
FAU - Esplen, Mary Jane
AU  - Esplen MJ
AD  - University Health Network, Toronto, Ontario, Canada.
FAU - Cappelli, Mario
AU  - Cappelli M
FAU - Wong, Jiahui
AU  - Wong J
FAU - Bottorff, Joan L
AU  - Bottorff JL
FAU - Hunter, Jon
AU  - Hunter J
FAU - Carroll, June
AU  - Carroll J
FAU - Dorval, Michel
AU  - Dorval M
FAU - Wilson, Brenda
AU  - Wilson B
FAU - Allanson, Judith
AU  - Allanson J
FAU - Semotiuk, Kara
AU  - Semotiuk K
FAU - Aronson, Melyssa
AU  - Aronson M
FAU - Bordeleau, Louise
AU  - Bordeleau L
FAU - Charlemagne, Nicole
AU  - Charlemagne N
FAU - Meschino, Wendy
AU  - Meschino W
LA  - eng
PT  - Journal Article
DEP - 20130313
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3612753
EDAT- 2013/03/15 06:00
MHDA- 2013/03/15 06:01
PMCR- 2013/03/13
CRDT- 2013/03/15 06:00
PHST- 2013/03/15 06:00 [entrez]
PHST- 2013/03/15 06:00 [pubmed]
PHST- 2013/03/15 06:01 [medline]
PHST- 2013/03/13 00:00 [pmc-release]
AID - bmjopen-2012-002227 [pii]
AID - 10.1136/bmjopen-2012-002227 [doi]
PST - epublish
SO  - BMJ Open. 2013 Mar 13;3(3):e002227. doi: 10.1136/bmjopen-2012-002227.