PMID- 23486000
OWN - NLM
STAT- MEDLINE
DCOM- 20130912
LR  - 20151119
IS  - 1423-0240 (Electronic)
IS  - 0378-584X (Linking)
VI  - 36
IP  - 3
DP  - 2013
TI  - Sudden extramedullary blast crisis of chronic myeloid leukemia manifesting as 
      T-cell lymphoblastic lymphoma.
PG  - 119-22
LID - 10.1159/000348681 [doi]
AB  - BACKGROUND: Chronic myeloid leukemia (CML) is usually diagnosed in the chronic 
      phase. An extramedullary blast crisis mimicking a T-cell lymphoma is a rare 
      finding. CASE REPORT: A 35-year-old man presented with multiple lymphadenopathy 2 
      months after diagnosis of Philadelphia chromosome (Ph)-positive CML in the 
      chronic phase. Cervical lymph node biopsy later indicated an extramedullary blast 
      crisis resembling T-cell lymphoblastic lymphoma (TLBL). The tumor mass was 
      composed of primitive lymphoid cells expressing terminal deoxynucleotidyl 
      transferase (TdT), CD3, CD43, CD5, CD99, and Bcl-2. Although the pathological 
      diagnosis, confirmed by 2 independent pathological centers, was more typical of 
      TLBL, fluorescence in situ hybridization (FISH) analysis showed the bcr-abl 
      fusion gene within the blastic tumor cells. The FISH finding confirmed that the 
      mass represented an extramedullary, immature blastic transformation of CML rather 
      than a de novo T-cell lymphoma. CONCLUSION: The diagnosis of de novo TLBL should 
      be suspected before excluding the extramedullary blast phase of CML.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Wei, Jia
AU  - Wei J
AD  - Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Huang, Mei
AU  - Huang M
FAU - Wang, Ying
AU  - Wang Y
FAU - Zhou, Jianfeng
AU  - Zhou J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20130225
PL  - Switzerland
TA  - Onkologie
JT  - Onkologie
JID - 7808556
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - Adult
MH  - Biomarkers, Tumor/*genetics
MH  - Blast Crisis/*diagnosis/*genetics
MH  - Diagnosis, Differential
MH  - False Positive Reactions
MH  - Fusion Proteins, bcr-abl/*genetics
MH  - Genetic Testing/*methods
MH  - Humans
MH  - Lymphoma, T-Cell/*diagnosis/*genetics
MH  - Male
EDAT- 2013/03/15 06:00
MHDA- 2013/09/13 06:00
CRDT- 2013/03/15 06:00
PHST- 2013/03/15 06:00 [entrez]
PHST- 2013/03/15 06:00 [pubmed]
PHST- 2013/09/13 06:00 [medline]
AID - 000348681 [pii]
AID - 10.1159/000348681 [doi]
PST - ppublish
SO  - Onkologie. 2013;36(3):119-22. doi: 10.1159/000348681. Epub 2013 Feb 25.