PMID- 23486871
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20151119
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 80
IP  - 14
DP  - 2013 Apr 2
TI  - Increased childhood incidence of narcolepsy in western Sweden after H1N1 
      influenza vaccination.
PG  - 1315-21
LID - 10.1212/WNL.0b013e31828ab26f [doi]
AB  - OBJECTIVES: To assess the incidence of narcolepsy between January 2000 and 
      December 2010 in children in western Sweden and its relationship to the Pandemrix 
      vaccination, and to compare the clinical and laboratory features of these 
      children. METHODS: The children were identified from all local and regional 
      pediatric hospitals, child rehabilitation centers, outpatient pediatric clinics, 
      and regional departments of neurophysiology. Data collection was performed with 
      the aid of a standardized data collection form, from medical records and 
      telephone interviews with patients and parents. The laboratory and 
      investigational data were carefully scrutinized. RESULTS: We identified 37 
      children with narcolepsy. Nine of them had onset of symptoms before the H1N1 
      vaccination and 28 had onset of symptoms in relationship to the vaccination. The 
      median age at onset was 10 years. All patients in the postvaccination group were 
      positive for human leukocyte antigen (HLA)-DQB1*0602. Nineteen patients in the 
      postvaccination group, compared with one in the prevaccination group, had a 
      clinical onset that could be dated within 12 weeks. CONCLUSION: Pandemrix 
      vaccination is a precipitating factor for narcolepsy, especially in combination 
      with HLA-DQB1*0602. The incidence of narcolepsy was 25 times higher after the 
      vaccination compared with the time period before. The children in the 
      postvaccination group had a lower age at onset and a more sudden onset than that 
      generally seen.
FAU - Szakacs, Attila
AU  - Szakacs A
AD  - Department of Children, County Hospital, Halmstad, Sweden.
FAU - Darin, Niklas
AU  - Darin N
FAU - Hallbook, Tove
AU  - Hallbook T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130313
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Autoantibodies)
RN  - 0 (Bacterial Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (P2RY11 protein, human)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 0 (Receptors, Purinergic P2)
RN  - 0 (Streptolysins)
RN  - 0 (streptolysin O)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.17 (TRIB2 protein, human)
SB  - IM
CIN - Neurology. 2013 Apr 2;80(14):1276-7. PMID: 23486883
MH  - Adolescent
MH  - Autoantibodies/blood
MH  - Bacterial Proteins/immunology
MH  - Calcium-Calmodulin-Dependent Protein Kinases
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Influenza, Human/*immunology
MH  - Intracellular Signaling Peptides and Proteins/immunology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Narcolepsy/blood/cerebrospinal fluid/*epidemiology/*etiology
MH  - Polymorphism, Genetic/genetics
MH  - Receptors, Antigen, T-Cell, alpha-beta/genetics
MH  - Receptors, Purinergic P2/genetics
MH  - Retrospective Studies
MH  - Streptolysins/immunology
MH  - Sweden/epidemiology
MH  - Tomography Scanners, X-Ray Computed
MH  - Vaccination/*adverse effects
EDAT- 2013/03/15 06:00
MHDA- 2013/05/25 06:00
CRDT- 2013/03/15 06:00
PHST- 2013/03/15 06:00 [entrez]
PHST- 2013/03/15 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - WNL.0b013e31828ab26f [pii]
AID - 10.1212/WNL.0b013e31828ab26f [doi]
PST - ppublish
SO  - Neurology. 2013 Apr 2;80(14):1315-21. doi: 10.1212/WNL.0b013e31828ab26f. Epub 
      2013 Mar 13.