PMID- 23487199
OWN - NLM
STAT- MEDLINE
DCOM- 20130911
LR  - 20220318
IS  - 1545-7222 (Electronic)
IS  - 0895-0172 (Linking)
VI  - 25
IP  - 1
DP  - 2013 Winter
TI  - BDNF val66met polymorphism is associated with age at onset and intensity of 
      symptoms of paranoid schizophrenia in a Polish population.
PG  - 88-94
LID - 10.1176/appi.neuropsych.11100234 [doi]
AB  - The brain-derived neurotrophic factor (BDNF) is one of the candidate genes for 
      schizophrenia. There is evidence that val66met polymorphism may be involved in 
      the pathophysiology of schizophrenia. The authors genotyped val66met (rs6265) 
      polymorphism of the BDNF gene in 208 inpatients with paranoid schizophrenia and 
      254 control subjects in a Polish population. There was no association between 
      val66met polymorphism and development of paranoid schizophrenia in either men or 
      women. However, an association was found between this polymorphism and age at 
      onset and psychopathology of paranoid schizophrenia. Men with the val/met 
      genotype had an earlier age at onset, and the val/val genotype predisposed to 
      more severe symptoms, particularly on the General Psychopathology Scale of the 
      Positive and Negative Symptoms Scale (PANSS-G). The analysis of PANSS single 
      items has shown that patients with the val/met genotype had higher scores on a 
      hallucinatory behavior item than those with other genotypes.
FAU - Suchanek, Renata
AU  - Suchanek R
AD  - Dept. of Medical Genetics, Medical University of Silesia, Sosnowiec, Poland. 
      rsuchanek@sum.edu.pl
FAU - Owczarek, Aleksander
AU  - Owczarek A
FAU - Paul-Samojedny, Monika
AU  - Paul-Samojedny M
FAU - Kowalczyk, Malgorzata
AU  - Kowalczyk M
FAU - Kucia, Krzysztof
AU  - Kucia K
FAU - Kowalski, Jan
AU  - Kowalski J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neuropsychiatry Clin Neurosci
JT  - The Journal of neuropsychiatry and clinical neurosciences
JID - 8911344
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - Poland/epidemiology
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia, Paranoid/*genetics
MH  - Sex Factors
MH  - Valine/*genetics
EDAT- 2013/03/15 06:00
MHDA- 2013/09/12 06:00
CRDT- 2013/03/15 06:00
PHST- 2013/03/15 06:00 [entrez]
PHST- 2013/03/15 06:00 [pubmed]
PHST- 2013/09/12 06:00 [medline]
AID - 1660498 [pii]
AID - 10.1176/appi.neuropsych.11100234 [doi]
PST - ppublish
SO  - J Neuropsychiatry Clin Neurosci. 2013 Winter;25(1):88-94. doi: 
      10.1176/appi.neuropsych.11100234.