PMID- 23488973
OWN - NLM
STAT- MEDLINE
DCOM- 20140331
LR  - 20161125
IS  - 1460-2709 (Electronic)
IS  - 1369-3786 (Linking)
VI  - 51
IP  - 7
DP  - 2013 Oct
TI  - The importance of pro-inflammatory and anti-inflammatory cytokines in 
      Pneumocystis jirovecii pneumonia.
PG  - 704-12
LID - 10.3109/13693786.2013.772689 [doi]
AB  - The role of pro-inflammatory and anti-inflammatory cytokines in Pneumocystis 
      jirovecii pneumonia (PcP) of non-AIDS immunocompromised patients remains unclear. 
      We measured the levels of pro-inflammatory cytokines including tumor necrosis 
      factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, IL-8, monocyte chemoattractant 
      protein-1 (MCP-1) and anti-inflammatory cytokines including IL-10 and 
      transforming growth factor (TGF)-beta1 in bronchoalveolar lavage fluid (BALF) and 
      blood in 36 non-AIDS immunocompromised patients with PcP diagnosed by BAL and 
      explored their clinical importance. The severity of PcP was determined by 
      arterial oxygen tension/fraction of inspired oxygen concentration (PaO2/FiO2) 
      ratio, the need of mechanical ventilation and the death. Twenty-five subjects 
      without evidence of lung abnormality were included as control group. Compared 
      with control group, PcP patients had significantly higher BALF levels of IL-1beta, 
      TNF-alpha, IL-6, IL-8 and MCP-1 and significantly higher blood levels of IL-10, 
      TGF-beta1, IL-8, IL-6 and MCP-1. For PcP patients, BALF levels of IL-8, IL-8/IL-10 
      ratio and IL-8/TGF-beta1 ratio and blood levels of IL-8 and IL-8/IL-10 ratio were 
      significantly higher in the patients with PaO2/FiO2 < 200 mmHg than in those with 
      PaO2/FiO2 > 200 mmHg. Similarly, significantly higher BALF levels of IL-8, 
      IL-8/IL-10 ratio, IL-1beta/IL-10, IL-1beta/TGF-beta1 ratio, MCP-1/TGF-beta1 ratio and 
      IL-8/TGF-beta1 ratio were found in the patients requiring mechanical ventilation and 
      in non-survivors. In summary, an imbalance of pro-inflammatory and 
      anti-inflammatory cytokines in BALF was found in PcP of non-AIDS 
      immunocompromised patients. BALF levels of IL-8, IL-8/IL-10 ratio, IL-1beta/IL-10 
      ratio, IL-1beta/TGF-beta1 ratio, MCP-1/TGF-beta1 ratio and IL-8/TGF-beta1 ratio may be of 
      value in assessing the severity of PcP and in predicting the outcome of the 
      patients.
FAU - Chou, Chung-Wei
AU  - Chou CW
AD  - * Institute of Clinical Medicine.
FAU - Lin, Fang-Chi
AU  - Lin FC
FAU - Tsai, Han-Chen
AU  - Tsai HC
FAU - Chang, Shi-Chuan
AU  - Chang SC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130314
PL  - England
TA  - Med Mycol
JT  - Medical mycology
JID - 9815835
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bronchoalveolar Lavage Fluid/*chemistry
MH  - Cytokines/*analysis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pneumocystis carinii/*immunology
MH  - Pneumonia, Pneumocystis/diagnosis/*immunology/*pathology
MH  - Prognosis
MH  - Severity of Illness Index
EDAT- 2013/03/16 06:00
MHDA- 2014/04/01 06:00
CRDT- 2013/03/16 06:00
PHST- 2013/03/16 06:00 [entrez]
PHST- 2013/03/16 06:00 [pubmed]
PHST- 2014/04/01 06:00 [medline]
AID - 10.3109/13693786.2013.772689 [doi]
PST - ppublish
SO  - Med Mycol. 2013 Oct;51(7):704-12. doi: 10.3109/13693786.2013.772689. Epub 2013 
      Mar 14.