PMID- 23489221
OWN - NLM
STAT- MEDLINE
DCOM- 20140327
LR  - 20220318
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 28
IP  - 8
DP  - 2013 Aug
TI  - Limited role of allergy testing in patients with eosinophilic gastrointestinal 
      disorders.
PG  - 1306-13
LID - 10.1111/jgh.12197 [doi]
AB  - BACKGROUND AND AIM: Allergies have been implicated in the pathogenesis of 
      eosinophilic gastrointestinal disorders, although it remains unknown what type of 
      allergen is closely associated with their development. The aim of this study is 
      to investigate the possible involvement of food and/or aeroallergen factors in 
      eosinophilic gastrointestinal disorders. METHODS: Eighteen patients with 
      eosinophilic esophagitis (EoE), 23 with eosinophilic gastroenteritis (EGE), and 
      28 healthy volunteers were enrolled. The levels of total serum immunoglobulin E 
      (IgE) and 33 different allergen-specific IgE antibodies, including those for six 
      foods used in a standard EoE elimination diet, were determined in each subject. 
      Serum antigen-specific IgE levels were measured using a chemiluminescence enzyme 
      immunoassay with a multiple antigen simultaneous test 33 (MAST33). The expression 
      patterns of specific antigens were compared among the groups. RESULTS: The mean 
      level of total IgE antibodies was significantly higher in patients with EGE 
      (553.6 +/- 115.3 IU/mL) than the healthy volunteers (230.6 +/- 87.1 IU/mL). Two 
      thirds of all subjects had sensitivity to at least one inhaled antigen. In 
      positive cases, allergies against multiple antigens were more frequently seen in 
      the EoE and EGE patients. Japanese cedar and dust mite aeroallergens were more 
      prevalent than food antigens. CONCLUSIONS: Consistent with higher levels of serum 
      total IgE antibodies, patients with EoE and EGE were frequently sensitized to 
      several different allergens. Reactions to aeroallergens were more prevalent in 
      these groups, although no particular antigen causing EoE and/or EGE was detected 
      by measuring serum antigen-specific IgE antibodies.
CI  - (c) 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing 
      Asia Pty Ltd.
FAU - Ishimura, Norihisa
AU  - Ishimura N
AD  - Department of Gastroenterology and Hepatology, Shimane University School of 
      Medicine, Izumo, Japan. ishimura@med.shimane-u.ac.jp
FAU - Furuta, Kenji
AU  - Furuta K
FAU - Sato, Shuichi
AU  - Sato S
FAU - Ishihara, Shunji
AU  - Ishihara S
FAU - Kinoshita, Yoshikazu
AU  - Kinoshita Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (Allergens)
RN  - 0 (Epitopes)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - Eosinophilic enteropathy
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Allergens/*immunology
MH  - Animals
MH  - Cedrus/immunology
MH  - Enteritis/*etiology/*immunology
MH  - Eosinophilia/*etiology/*immunology
MH  - Eosinophilic Esophagitis/*etiology/*immunology
MH  - Epitopes
MH  - Female
MH  - Food/adverse effects
MH  - Food Hypersensitivity/complications/immunology
MH  - Gastritis/*etiology/*immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - *Immunologic Tests
MH  - Male
MH  - Middle Aged
MH  - Pyroglyphidae/immunology
MH  - Young Adult
OTO - NOTNLM
OT  - allergens
OT  - eosinophilic gastrointestinal disorders
OT  - immunoglobulin E
OT  - serum antigen-specific IgE
EDAT- 2013/03/16 06:00
MHDA- 2014/03/29 06:00
CRDT- 2013/03/16 06:00
PHST- 2013/03/04 00:00 [accepted]
PHST- 2013/03/16 06:00 [entrez]
PHST- 2013/03/16 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
AID - 10.1111/jgh.12197 [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2013 Aug;28(8):1306-13. doi: 10.1111/jgh.12197.