PMID- 23489692
OWN - NLM
STAT- MEDLINE
DCOM- 20130612
LR  - 20130315
IS  - 0393-974X (Print)
IS  - 0393-974X (Linking)
VI  - 27
IP  - 1
DP  - 2013 Jan-Mar
TI  - p63 expression in laryngeal squamous cell carcinoma is related to tumor 
      extension, histologic grade, lymph node involvement and clinical stage.
PG  - 121-9
AB  - To analyse the relationship of the immunohistochemical p63 expression with 
      tumoral extent, histologic grade, lymph node involvement and clinical stage in 
      laryngeal squamous cell carcinoma (LSCC), a series of 81 patients with primary 
      LSCC treated by primary surgery was retrospectively evaluated. 
      Immunohistochemistry was performed on formalin-fixed and paraffin-embedded tissue 
      blocks from surgical samples. Clinicopathologic data were correlated with the p63 
      staining results. Differences in p63 immunoreactivity between the different 
      groups were compared using both parametric analysis of variance (ANOVA) and 
      non-parametric Kruskal-Wallis test. Statistical significance was set at p less 
      than 0.05. All statistical analyses were performed using the R statistical 
      package. We found a statistically significant association between p63 protein 
      expression and increase of tumor extension (T1 vs T3), of histological grading, 
      of level of lymph node involvement (N0 vs N1 and N2), and clinical stage (I vs 
      IV). Our findings suggest that abnormal expression of p63 may be involved in the 
      early phases of laryngeal tumorigenesis and this oncoprotein might become a 
      useful predictor of clinical outcome.
FAU - Re, M
AU  - Re M
AD  - Department of Otorhinolaryngology, Polytechnic University of the Marche United 
      Hospitals, Torrette, Italy. remassimo@hotmail.com
FAU - Magliulo, G
AU  - Magliulo G
FAU - Ferrante, L
AU  - Ferrante L
FAU - Zizzi, A
AU  - Zizzi A
FAU - Santarelli, A
AU  - Santarelli A
FAU - Stramazzotti, D
AU  - Stramazzotti D
FAU - Lo Muzio, L
AU  - Lo Muzio L
FAU - Goteri, G
AU  - Goteri G
FAU - Rubini, C
AU  - Rubini C
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Biol Regul Homeost Agents
JT  - Journal of biological regulators and homeostatic agents
JID - 8809253
RN  - 0 (TP63 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism/*pathology
MH  - Lymph Nodes/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - Transcription Factors/*metabolism
MH  - Tumor Suppressor Proteins/*metabolism
EDAT- 2013/03/16 06:00
MHDA- 2013/06/13 06:00
CRDT- 2013/03/16 06:00
PHST- 2013/03/16 06:00 [entrez]
PHST- 2013/03/16 06:00 [pubmed]
PHST- 2013/06/13 06:00 [medline]
AID - 11 [pii]
PST - ppublish
SO  - J Biol Regul Homeost Agents. 2013 Jan-Mar;27(1):121-9.