PMID- 23490273
OWN - NLM
STAT- MEDLINE
DCOM- 20140311
LR  - 20130621
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Linking)
VI  - 18
IP  - 5
DP  - 2013 Jul
TI  - Gender difference in allergic airway remodelling and immunoglobulin production in 
      mouse model of asthma.
PG  - 797-806
LID - 10.1111/resp.12078 [doi]
AB  - BACKGROUND AND OBJECTIVE: Epidemiological studies have shown that the prevalence 
      of adult asthma and severe asthma is higher in women. It has also been reported 
      that female mice are more susceptible than males to the development of allergic 
      airway inflammation and airway hyperresponsiveness (AHR). The influence of gender 
      difference in the pathogenesis of severe asthma, especially airway remodelling in 
      an animal model, has been studied rarely. We investigated gender difference in 
      the development of airway remodelling using a long-term antigen-challenged mouse 
      asthma model. METHODS: Following ovalbumin (OVA)/alum intraperitoneal injection, 
      male or female mice (BALB/c) were challenged with aerosolized 1% OVA on 3 
      days/week for 5 weeks, and differences in AHR, airway inflammation and airway 
      remodelling between the sexes were investigated. RESULTS: In OVA-sensitized and 
      OVA-challenged (OVA/OVA) female mice, eosinophils, lymphocytes, T-helper type 2 
      cytokines and growth factors in bronchoalveolar lavage fluid were increased 
      compared with OVA/OVA male mice. Histological features of airway remodelling were 
      also increased in OVA/OVA female mice. Serum total and OVA-specific 
      immunoglobulin E (IgE) and serum IgA were significantly elevated in OVA/OVA 
      female mice. CONCLUSIONS: These results indicate that female mice experience more 
      airway remodelling compared with male mice. These results suggest the involvement 
      of sex hormones and gender differences in cellular functions in airway 
      remodelling.
CI  - (c) 2013 The Authors. Respirology (c) 2013 Asian Pacific Society of Respirology.
FAU - Takeda, Masahide
AU  - Takeda M
AD  - Department of Infection, Allergy, Clinical Immunology and Laboratory Medicine, 
      Akita University Graduate School of Medicine, Akita.
FAU - Tanabe, Masako
AU  - Tanabe M
FAU - Ito, Wataru
AU  - Ito W
FAU - Ueki, Shigeharu
AU  - Ueki S
FAU - Konnno, Yasunori
AU  - Konnno Y
FAU - Chihara, Mami
AU  - Chihara M
FAU - Itoga, Masamichi
AU  - Itoga M
FAU - Kobayashi, Yoshiki
AU  - Kobayashi Y
FAU - Moritoki, Yuki
AU  - Moritoki Y
FAU - Kayaba, Hiroyuki
AU  - Kayaba H
FAU - Chihara, Junichi
AU  - Chihara J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Airway Remodeling/*physiology
MH  - Animals
MH  - Asthma/chemically induced/*metabolism/*physiopathology
MH  - Chemokines/metabolism
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Gonadal Steroid Hormones/physiology
MH  - Immunoglobulin A/*metabolism
MH  - Immunoglobulin E/*metabolism
MH  - Immunoglobulin G/*metabolism
MH  - Injections, Intraperitoneal
MH  - Intercellular Signaling Peptides and Proteins/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/administration & dosage/adverse effects
MH  - *Sex Factors
EDAT- 2013/03/16 06:00
MHDA- 2014/03/13 06:00
CRDT- 2013/03/16 06:00
PHST- 2012/07/11 00:00 [received]
PHST- 2012/12/17 00:00 [revised]
PHST- 2012/12/17 00:00 [accepted]
PHST- 2013/03/16 06:00 [entrez]
PHST- 2013/03/16 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
AID - 10.1111/resp.12078 [doi]
PST - ppublish
SO  - Respirology. 2013 Jul;18(5):797-806. doi: 10.1111/resp.12078.