PMID- 23490376
OWN - NLM
STAT- MEDLINE
DCOM- 20130828
LR  - 20131121
IS  - 1365-2893 (Electronic)
IS  - 1352-0504 (Linking)
VI  - 20
IP  - 4
DP  - 2013 Apr
TI  - PD-1 expression on CTL may be related to more severe liver damage in CHB patients 
      with HBV genotype C than in those with genotype B infection.
PG  - e1-2
LID - 10.1111/jvh.12009 [doi]
AB  - Compared with Chronic hepatitis B (CHB) patients infected with genotype B, those 
      infected with genotype C have higher hepatic histopathological activity and 
      higher level of alanine aminotransferase (ALT). Our previous studies suggest that 
      this phenomenon is related to lower level of HBV specific cytotoxic T lymphocyte 
      (CTL) of patients infected with genotype C than those infected with genotype B, 
      but its mechanism was not clear. The aim of present study was to explain the 
      possible mechanism of lower level of HBV specific CTL and more serious liver 
      function damage of patients infected with genotype C than those infected with 
      genotype B through study on relationship between expression of HBV specific CTL 
      surface programmed death receptor-1 (PD-1) and viral genotypes of CHB patients. A 
      total of 100 CHB patients were studied, human leukocyte antigen (HLA)-A2 
      positive, hepatitis B virus (HBV) DNA>10(3) copies/ml, of which 48 cases were 
      genotype C (48%) positive, and 52 cases were genotype B positive (52%). 
      Expression of Peripheral blood HBV specific CTL surface PD-1, levels of HBV 
      specific CTL, HBV DNA, ALT and total bilirubin (TBil) of patients infected with 
      genotype C and B were compared. Expression of HBV specific CTL surface PD-1 of 
      CHB patients infected with genotype C was significantly higher than that of 
      patients infected with genotype B, t = 17.57, P < 0.001, level of HBV specific 
      CTL was significantly lower than that of patients infected with genotype B, t = 
      23.64, P < 0.001, level of HBV DNA was significantly higher than that of patients 
      infected with genotype B, t = 9.43, P < 0.001, level of ALT was significantly 
      higher than that of patients infected with genotype B, t = 13.42, P < 0.001. 
      Expression of peripheral blood HBV specific CTL surface PD-1 of CHB patients 
      infected with genotype C was significantly higher than that of patients infected 
      with genotype B, resulting in lower level of HBV specific CTL and higher level of 
      HBV DNA of patients infected with genotype C than those of patients infected with 
      genotype B. So liver function damage of CHB patients infected with genotype C was 
      more serious than those infected with genotype B.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Xibing, G
AU  - Xibing G
AD  - Department of Hepatology, Wuxi Hospital for Infectious Diseases, Wuxi, Jiangsu, 
      China. gxb188681@sina.com
FAU - Xiaojuan, Y
AU  - Xiaojuan Y
FAU - Juanhua, W
AU  - Juanhua W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121030
PL  - England
TA  - J Viral Hepat
JT  - Journal of viral hepatitis
JID - 9435672
RN  - 0 (DNA, Viral)
RN  - 0 (PDCD1 protein, human)
RN  - 0 (Programmed Cell Death 1 Receptor)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Bilirubin/blood
MH  - DNA, Viral/blood
MH  - Genotype
MH  - Hepatitis B virus/classification/*genetics/*immunology
MH  - Hepatitis B, Chronic/*immunology/*virology
MH  - Humans
MH  - Liver/immunology/*pathology/virology
MH  - Programmed Cell Death 1 Receptor/*biosynthesis
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - Viral Load
EDAT- 2013/03/16 06:00
MHDA- 2013/08/29 06:00
CRDT- 2013/03/16 06:00
PHST- 2012/04/01 00:00 [received]
PHST- 2012/08/01 00:00 [accepted]
PHST- 2013/03/16 06:00 [entrez]
PHST- 2013/03/16 06:00 [pubmed]
PHST- 2013/08/29 06:00 [medline]
AID - 10.1111/jvh.12009 [doi]
PST - ppublish
SO  - J Viral Hepat. 2013 Apr;20(4):e1-2. doi: 10.1111/jvh.12009. Epub 2012 Oct 30.