PMID- 23493298
OWN - NLM
STAT- MEDLINE
DCOM- 20130529
LR  - 20220321
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 54
IP  - 4
DP  - 2013 Apr 5
TI  - Reproducibility of thickness measurements of macular inner retinal layers using 
      SD-OCT with or without correction of ocular rotation.
PG  - 2562-70
LID - 10.1167/iovs.12-10552 [doi]
AB  - PURPOSE: To evaluate the intervisit reproducibility of spectral-domain optical 
      coherence tomography (SD-OCT) measurement of the macular retinal nerve fiber 
      layer thickness (mRNFLT); combined ganglion cell layer and inner plexiform layer 
      (GCL+IPL) thickness; and ganglion cell complex (GCC) thicknesses (sum of mRNFLT 
      and GCL+IPL thicknesses) compared with that of circumpapillary RNFLT (cpRNFLT) 
      and the effect of ocular rotation on reproducibility. METHODS: SD-OCT imaging was 
      performed twice on different days in one eye of 58 normal subjects and 73 
      glaucoma patients. The reproducibility was evaluated for the entire 4.8-mm x 
      4.8-mm macular area and subareas (upper and lower halves, 2 x 2, 4 x 4, and 8 x 8 
      grids), and the 360 degrees , upper, and lower halves mean cpRNFLT with and without 
      correction of ocular rotation. RESULTS: The coefficients of variation (CVs) of 
      GCL+IPL and GCC thickness measurements averaged below 1.0% for the entire and 
      upper and lower half macular areas, and below 4.2% in the macular subareas in 
      normal and glaucoma eyes, which were significantly smaller (P < 0.001) than those 
      of mRNFLT measurements in the same areas of the same eyes. The CVs of mRNFLT 
      measurements were significantly smaller than those of the cpRNFLT only in the 
      lower half mean area in normal eyes. The reproducibility was minimally affected 
      by correction of ocular rotation or presence of glaucoma. CONCLUSIONS: The 
      reproducibility of the macular (GCL+IPL) and GCC thickness measurements was 
      better than that of mRFNLT and cpRNFLT in normal and glaucoma eyes and minimally 
      affected by correction of ocular rotation.
FAU - Hirasawa, Hiroyo
AU  - Hirasawa H
AD  - Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 
      Tokyo, Japan. takamoto-tky@umin.ac.jp
FAU - Araie, Makoto
AU  - Araie M
FAU - Tomidokoro, Atsuo
AU  - Tomidokoro A
FAU - Saito, Hitomi
AU  - Saito H
FAU - Iwase, Aiko
AU  - Iwase A
FAU - Ohkubo, Shinji
AU  - Ohkubo S
FAU - Sugiyama, Kazuhisa
AU  - Sugiyama K
FAU - Ootani, Tomohiro
AU  - Ootani T
FAU - Kishi, Shoji
AU  - Kishi S
FAU - Matsushita, Kenji
AU  - Matsushita K
FAU - Maeda, Naoyuki
AU  - Maeda N
FAU - Hangai, Masanori
AU  - Hangai M
FAU - Yoshimura, Nagahisa
AU  - Yoshimura N
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20130405
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Glaucoma/*diagnosis
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Intraocular Pressure
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Reproducibility of Results
MH  - Retinal Ganglion Cells/*pathology
MH  - Rotation
MH  - Tomography, Optical Coherence/*standards
MH  - Tonometry, Ocular
EDAT- 2013/03/16 06:00
MHDA- 2013/05/31 06:00
CRDT- 2013/03/16 06:00
PHST- 2013/03/16 06:00 [entrez]
PHST- 2013/03/16 06:00 [pubmed]
PHST- 2013/05/31 06:00 [medline]
AID - iovs.12-10552 [pii]
AID - 10.1167/iovs.12-10552 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2013 Apr 5;54(4):2562-70. doi: 10.1167/iovs.12-10552.